4.7 Review

Cervical Cancer Protection in Japan: Where Are We?

Journal

VACCINES
Volume 9, Issue 11, Pages -

Publisher

MDPI
DOI: 10.3390/vaccines9111263

Keywords

HPV vaccine; cervical cancer; government suspension of recommendation; adverse events; vaccine hesitancy

Funding

  1. Health and Labor Science Research Grant [20EA1025]
  2. Japan Agency for Medical Research and Development [21ck0106562h0002]

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Despite the widely accepted national immunization program for HPV vaccination in Japan, the suspension of government recommendation due to adverse events led to a drastic drop in vaccination rates. Even with the introduction of a new vaccine, Japanese mothers remain hesitant, and it is crucial for educational and medical institutions to work harder in informing parents and children about the benefits of HPV vaccines.
In Japan, government subsidies for human papillomavirus (HPV) vaccination of girls aged 13-16 commenced in 2010. By early 2013, vaccination had become a widely accepted national immunization program. However, in June of 2013, the Ministry of Health, Labor, and Welfare (MHLW), the government's lead agency, suspended its recommendation for vaccination in response to reports of adverse vaccine events. The rate of HPV vaccination quickly dropped from 70% to almost zero, where it has lingered for eight years. In 2020, a new 9-valent HPV vaccine was licensed in Japan. The momentum seemed to be building for the resumption of HPV vaccinations, yet Japanese mothers remain widely hesitant about vaccinating their daughters, despite the well-proven safety and efficacy of the HPV vaccines. The Japanese government and our educational and medical institutions must work harder as a team to inform our parents and their children about the life-saving benefits of the HPV vaccine, and at the same time, we must respond to all their concerns and questions. The vaccine hesitancy of unvaccinated women born in 2000 and thereafter is a natural consequence of the suspension of the government's recommendation. We must also take every possible measure to reduce the significant risk for cervical cancer these women have.

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