4.7 Article

Recombinant BCG Expressing the Subunit 1 of Pertussis Toxin Induces Innate Immune Memory and Confers Protection against Non-Related Pathogens

Related references

Note: Only part of the references are listed.
Review Infectious Diseases

100 years of Mycobacterium bovis bacille Calmette-Guerin

Christoph Lange et al.

Summary: The BCG vaccine, initially designed for cattle, has saved many lives since its first administration to a newborn in Paris in 1921. While providing strong protection against miliary and meningeal tuberculosis in children, it is less effective in preventing pulmonary tuberculosis in adults. It has also shown non-specific benefits against non-tuberculous infections and immunotherapeutic benefits in certain cancers.

LANCET INFECTIOUS DISEASES (2022)

Article Medicine, Research & Experimental

BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers

Magali Noval Rivas et al.

Summary: In this study of healthcare workers, those with a history of BCG vaccination had lower seroprevalence of anti-SARS-CoV-2 IgG and reported fewer COVID-19-related symptoms compared to those without BCG vaccination. This suggests a potential protective effect of BCG vaccination against SARS-CoV-2 infection, warranting further large-scale clinical trials for confirmation.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Editorial Material Immunology

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Maziar Divangahi et al.

Summary: Researchers are working towards establishing a set of experimental standards to reach consensus on defining trained immunity, which will help advance research in this field.

NATURE IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

The association of Coronavirus Disease-19 mortality and prior bacille Calmette-Guerin vaccination: a robust ecological analysis using unsupervised machine learning

Nathan A. Brooks et al.

Summary: The study found that countries with active BCG vaccination programs for the past 15 years had lower COVID-19 related mortality rates, with mortality rates increasing significantly with a higher percentage of population over 65. A higher total population and longer implementation of BCG vaccination programs were significantly associated with improved COVID-19 related mortality rates.

SCIENTIFIC REPORTS (2021)

Article Immunology

MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies

Andrew D. White et al.

Summary: The study found that intradermal vaccination with MTBVAC in adult rhesus macaques induced immune responses that led to improved outcomes after M. tuberculosis challenge, supporting the potential of MTBVAC as an effective prophylactic vaccine for tuberculosis vaccination campaigns.

NPJ VACCINES (2021)

Article Medicine, General & Internal

BCG vaccination improves DTaP immune responses in mice and is associated with lower pertussis incidence in ecological epidemiological studies

Esther Broset et al.

Summary: The study showed that BCG and MTBVAC administered before DTaP can induce Th1 immune responses against diphtheria, tetanus, and pertussis in mice, while DTaP alone fails to trigger the same response. Analysis of human epidemiological data revealed that countries using both DTaP and BCG had significantly lower pertussis incidence compared to countries using only DTaP.

EBIOMEDICINE (2021)

Review Immunology

Thirty years of recombinant BCG: new trends for a centenary vaccine

Lazaro M. Marques-Neto et al.

Summary: The global perception of the potential of BCG and rBCG in various applications is on the rise, with current knowledge and development status being reviewed. Experts have high expectations for new tuberculosis vaccines and advancements in BCG technology, with systems biology and large-scale production processes playing crucial roles in supporting vaccine development. The next few years are expected to consolidate broader applications of BCG and provide insights into improvements using recombinant BCG technology.

EXPERT REVIEW OF VACCINES (2021)

Article Cell Biology

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

Michel P. M. Vierboom et al.

Summary: BCG vaccination can enhance protection against pathogens by inducing epigenetic and metabolic reprogramming of innate immune cells, known as trained immunity. In rhesus macaques, intravenous BCG was shown to better protect against Mycobacterium tuberculosis infection and TB disease compared to standard intradermal vaccination, correlating with local adaptive immune signatures. Additionally, mucosal vaccination, either with BCG or the MTBVAC candidate, was found to enhance innate cytokine production by monocytes derived from blood and bone marrow, showing metabolic rewiring typical of trained immunity.

CELL REPORTS MEDICINE (2021)

Review Immunology

Immunological memory: What's in a name?

Thomas Pradeu et al.

IMMUNOLOGICAL REVIEWS (2018)

Editorial Material Immunology

Innate Immune Memory: Time foe Adopting a Correct Terminology

Diana Boraschi et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Immunology

Innate Immune Memory in Invertebrate Metazoans: A Critical Appraisal

Daniela Melillo et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Cell Biology

Molecular mechanisms of innate memory and tolerance to LPS

John J. Seeley et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2017)

Review Immunology

What Have We Learnt about BCG Vaccination in the Last 20 Years?

Hazel M. Dockrell et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Immunology

In Vitro Experimental Model of Trained Innate Immunity in Human Primary Monocytes

Siroon Bekkering et al.

CLINICAL AND VACCINE IMMUNOLOGY (2016)

Review Immunology

Immune memory in invertebrates

Barbara Milutinovic et al.

SEMINARS IN IMMUNOLOGY (2016)

Editorial Material Parasitology

A Novel Mechanism of Immune Memory Unveiled at the Invertebrate-Parasite Interface

Christine Coustau et al.

TRENDS IN PARASITOLOGY (2016)

Article Cell Biology

Immunometabolic Pathways in BCG-Induced Trained Immunity

Rob J. W. Arts et al.

CELL REPORTS (2016)

Article Multidisciplinary Sciences

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Johanneke Kleinnijenhuis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Immunology

Mycobacterial signaling through toll-like receptors

Joyoti Basu et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2012)

Article Microbiology

Trained Immunity: A Memory for Innate Host Defense

Mihai G. Netea et al.

CELL HOST & MICROBE (2011)

Article Biochemistry & Molecular Biology

Enhancement of Th1 Lung Immunity Induced by Recombinant Mycobacterium bovis Bacillus Calmette-Guerin Attenuates Airway Allergic Disease

Ana P. Christ et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2010)

Article Oncology

The therapeutic potential of recombinant BCG expressing the antigen S1PT in the intravesical treatment of bladder cancer

Priscila M. Andrade et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2010)

Article Oncology

Immunomodulatory effects of recombinant BCG expressing pertussis toxin on TNF-alpha and IL-10 in a bladder cancer model

Daher C. Chade et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2008)