4.7 Review

Regenerative Endodontics and Minimally Invasive Dentistry: Intertwining Paths Crossing Over Into Clinical Translation

Related references

Note: Only part of the references are listed.
Article Cell Biology

Exosomes derived from lipopolysaccharide-preconditioned human dental pulp stem cells regulate Schwann cell migration and differentiation

Jiabei Li et al.

Summary: This study found that exosomes from human dental pulp stem cells can promote the proliferation, migration, and odontogenic differentiation of Schwann cells. Exosomes pre-treated with LPS showed better capability in regulating Schwann cells migration and odontogenic differentiation compared to untreated exosomes.

CONNECTIVE TISSUE RESEARCH (2021)

Article Cell Biology

Conditioned medium derived from 3D tooth germs: A novel cocktail for stem cell priming and early in vivo pulp regeneration

Tengfei Zhou et al.

Summary: The study showed that the conditioned medium from 3D tooth germs can enhance the proliferation and differentiation of DPSCs, promoting pulp regeneration, with a protein profile containing more odontogenic and angiogenic growth factors.

CELL PROLIFERATION (2021)

Review Dentistry, Oral Surgery & Medicine

Current strategies for conservative endodontic access cavity preparation techniques-systematic review, meta-analysis, and decision-making protocol

Benoit Ballester et al.

Summary: A systematic review was conducted to compare different endodontic access cavity (AC) designs, revealing that conservative AC designs are beneficial in reducing the risk of tooth fracture, while ultraconservative AC designs may be applicable in limited cases. However, there is currently insufficient evidence to support the application of truss AC designs.

CLINICAL ORAL INVESTIGATIONS (2021)

Article Dentistry, Oral Surgery & Medicine

Clinical and Radiographic Outcomes of Regenerative Endodontic Procedures in Traumatized Immature Permanent Teeth: Interappointment Dressing or Single-Visit?

Ana Carolina C. L. Cerqueira-Neto et al.

Summary: This study compared clinical and radiographic outcomes of regenerative endodontic procedures (REPs) between interappointment dressing or single-visit protocols. The results showed that both treatment approaches resulted in similar clinical and radiographic outcomes.

JOURNAL OF ENDODONTICS (2021)

Article Dentistry, Oral Surgery & Medicine

Aerosols Generated during Endodontic Treatment: A Special Concern during the Coronavirus Disease 2019 Pandemic

Mason Bahador et al.

Summary: This study aimed to investigate aerosolized microorganisms during endodontic emergencies and nonsurgical root canal therapy, exploring their spread and spatial distribution. The results showed that pulpotomy generated fewer aerosolized microorganisms compared to pulpectomy and NSRCT, with patient proximity and treatment duration being factors in contamination levels.

JOURNAL OF ENDODONTICS (2021)

Article Anatomy & Morphology

Effect of human dental pulp stem cell conditioned medium in the dentin-pulp complex regeneration: A pilot in vivo study

Giovanna Sarra et al.

Summary: This study evaluated the effects of human dental pulp stem cell conditioned medium on dental pulp tissue response to vital pulp therapy. The results showed that the conditioned medium, when combined with MTA, promoted dentin-pulp complex regeneration, indicating promising potential for regenerative dentistry studies.

TISSUE & CELL (2021)

Article Engineering, Biomedical

A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes

Shikun Wei et al.

Summary: This study developed a hydrogel system for the treatment of chronic infected wounds, which can effectively regulate inflammation and enhance collagen deposition and angiogenesis by using antimicrobial peptides and PRP. The hydrogel showed sustained-release capacity, anti-bacterial activity against pathogenic strains, and promoted fibroblast cells proliferation and migration. Additionally, the hydrogel accelerated wound healing in diabetic mouse infection, leading to improved collagen deposition, reduced bacterial load, and balanced inflammatory response.

ACTA BIOMATERIALIA (2021)

Article Materials Science, Biomaterials

Highly Structured 3D Electrospun Conical Scaffold: A Tool for Dental Pulp Regeneration

Lisa Terranova et al.

Summary: A new treatment procedure for dental pulp regeneration utilizing cell homing strategy and relevant scaffold design has been proposed. The gelatin-coated membrane showed improved biocompatibility and cell viability. The effectiveness of using 3D conical scaffolds for culturing DPSCs was demonstrated, indicating the suitability of the scaffold architecture for cell migration.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

Review Dentistry, Oral Surgery & Medicine

Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Antonios Glynis et al.

Summary: Based on moderate-quality evidence, Regenerative Endodontic Procedures (REPs) appear to be a viable treatment alternative for mature necrotic teeth with periapical lesions. Well-designed randomized controlled trials (RCTs) may provide confirmatory evidence and lay the groundwork for standardizing the therapeutic protocol of REPs.

JOURNAL OF ENDODONTICS (2021)

Article Dentistry, Oral Surgery & Medicine

Impact of Canal Taper and Access Cavity Design on the Life Span of an Endodontically Treated Mandibular Molar: A Finite Element Analysis

Mostafa M. A. Elkholy et al.

Summary: The study found that access cavity design has a greater impact on the lifespan of mandibular first molars than root canal preparation taper. Stress patterns migrate apically along the root surface, concentrating on the mesial aspect of the mesial root and the furcation area's outer surface.

JOURNAL OF ENDODONTICS (2021)

Article Materials Science, Biomaterials

Concentrated growth factor regulates the macrophage-mediated immune response

Haiyun Luo et al.

Summary: The study demonstrates that concentrated growth factor (CGF) can regulate macrophage functional activities, promoting tissue regeneration through a favorable immune response.

REGENERATIVE BIOMATERIALS (2021)

Review Dentistry, Oral Surgery & Medicine

The effect of ozone therapy in root canal disinfection: a systematic review

E. J. N. L. Silva et al.

INTERNATIONAL ENDODONTIC JOURNAL (2020)

Article Dentistry, Oral Surgery & Medicine

Effect of the Periapical Inflammatory Plug on Dental Pulp Regeneration: A Histologic In Vivo Study

Samer H. Zaky et al.

JOURNAL OF ENDODONTICS (2020)

Article Microbiology

Lactobacillus plantarum lipoteichoic acid disrupts mature Enterococcus faecalis biofilm

A. Reum Kim et al.

JOURNAL OF MICROBIOLOGY (2020)

Review Medicine, General & Internal

Pulp-Dentin Tissue Healing Response: A Discussion of Current Biomedical Approaches

Dishant Shah et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Medicine, General & Internal

Pulp-Derived Exosomes in a Fibrin-Based Regenerative Root Filling Material

Anja Ivica et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Dentistry, Oral Surgery & Medicine

DOES THE ETIOLOGY OF PULP NECROSIS AFFECT REGENERATIVE ENDODONTIC TREATMENT OUTCOMES? A SYSTEMATIC REVIEW AND META-ANALYSES

Simay Koc et al.

JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE (2020)

Review Dentistry, Oral Surgery & Medicine

Coronavirus Disease 19 (COVID-19): Implications for Clinical Dental Care

Amber Ather et al.

JOURNAL OF ENDODONTICS (2020)

Article Dentistry, Oral Surgery & Medicine

Dentin Conditioning Protocol for Regenerative Endodontic Procedures

Hacer Aksel et al.

JOURNAL OF ENDODONTICS (2020)

Article Dentistry, Oral Surgery & Medicine

Standardization of Endodontic Access Cavities Based on 3-dimensional Quantitative Analysis of Dentin and Enamel Removed

Almira Isufi et al.

JOURNAL OF ENDODONTICS (2020)

Review Dentistry, Oral Surgery & Medicine

Clinical endodontic management during the COVID-19 pandemic: a literature review and clinical recommendations

A. A. Azim et al.

INTERNATIONAL ENDODONTIC JOURNAL (2020)

Review Dentistry, Oral Surgery & Medicine

Current status on minimal access cavity preparations: a critical analysis and a proposal for a universal nomenclature

E. J. N. L. Silva et al.

INTERNATIONAL ENDODONTIC JOURNAL (2020)

Article Dentistry, Oral Surgery & Medicine

Contemporary Microbial and Antimicrobial Considerations in Regenerative Endodontic Therapy

Ashraf F. Fouad

JOURNAL OF ENDODONTICS (2020)

Article Cell & Tissue Engineering

Matrix-Bound Nanovesicles: The Effects of Isolation Method upon Yield, Purity, and Function

Lina M. Quijano et al.

TISSUE ENGINEERING PART C-METHODS (2020)

Editorial Material Dentistry, Oral Surgery & Medicine

Dissecting dentine-pulp injury and wound healing responses: consequences for regenerative endodontics

H. F. Duncan et al.

INTERNATIONAL ENDODONTIC JOURNAL (2019)

Article Dentistry, Oral Surgery & Medicine

Regenerative Endodontics: A Systematic Analysis of the Failed Cases

Waleed Almutairi et al.

JOURNAL OF ENDODONTICS (2019)

Article Dentistry, Oral Surgery & Medicine

Effect of a Residual Biofilm on Release of Transforming Growth Factor β1 from Dentin

Ritter Cameron et al.

JOURNAL OF ENDODONTICS (2019)

Article Dentistry, Oral Surgery & Medicine

EDTA conditioning of circumpulpal dentine induces dentinogenic events in pulpotomized miniature swine teeth

D. Tziafas et al.

INTERNATIONAL ENDODONTIC JOURNAL (2019)

Article Engineering, Biomedical

A novel patient-specific three-dimensional drug delivery construct for regenerative endodontics

Marco C. Bottino et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2019)

Review Biotechnology & Applied Microbiology

Antimicrobial Properties of Extracellular Matrix Scaffolds for Tissue Engineering

German R. Jimenez-Gastelum et al.

BIOMED RESEARCH INTERNATIONAL (2019)

Review Dentistry, Oral Surgery & Medicine

Effectiveness and clinical implications of the use of topical antibiotics in regenerative endodontic procedures: a review

P. Montero-Miralles et al.

INTERNATIONAL ENDODONTIC JOURNAL (2018)

Article Dentistry, Oral Surgery & Medicine

Exosomes with Highly Angiogenic Potential for Possible Use in Pulp Regeneration

Xuehong Xian et al.

JOURNAL OF ENDODONTICS (2018)

Article Dentistry, Oral Surgery & Medicine

Novel Endodontic Disinfection Approach Using Catalytic Nanoparticles

Sarah Bukhari et al.

JOURNAL OF ENDODONTICS (2018)

Article Dentistry, Oral Surgery & Medicine

The Effects of Irrigants on the Survival of Human Stem Cells of the Apical Papilla, Including Endocyn

Mark B. Scott et al.

JOURNAL OF ENDODONTICS (2018)

Article Dentistry, Oral Surgery & Medicine

Effect of Residual Bacteria on the Outcome of Pulp Regeneration In Vivo

P. Verma et al.

JOURNAL OF DENTAL RESEARCH (2017)

Article Dentistry, Oral Surgery & Medicine

Antimicrobial Efficacy of Triple Antibiotic-eluting Polymer Nanofibers against Multispecies Biofilm

Maria T. P. Albuquerque et al.

JOURNAL OF ENDODONTICS (2017)

Article Dentistry, Oral Surgery & Medicine

Regenerative Endodontics for Adult Patients

Ling He et al.

JOURNAL OF ENDODONTICS (2017)

Article Dentistry, Oral Surgery & Medicine

Effect of Bacterial Biofilm on the Osteogenic Differentiation of Stem Cells of Apical Papilla

Lakshmi Vishwanat et al.

JOURNAL OF ENDODONTICS (2017)

Article Dentistry, Oral Surgery & Medicine

Evaluation of the Role of Probiotics in Endodontic Treatment: A Preliminary Study

Aarti Bohora et al.

JOURNAL OF INTERNATIONAL SOCIETY OF PREVENTIVE AND COMMUNITY DENTISTRY (2017)

Editorial Material Dentistry, Oral Surgery & Medicine

Regenerative endodontics A way forward

Anibal Diogenes et al.

JOURNAL OF THE AMERICAN DENTAL ASSOCIATION (2016)

Article Dentistry, Oral Surgery & Medicine

Evaluation of Cold Plasma Treatment and Safety in Disinfecting 3-week Root Canal Enterococcus faecalis Biofilm In Vitro

Yinglong Li et al.

JOURNAL OF ENDODONTICS (2015)

Article Dentistry, Oral Surgery & Medicine

LL37 induces VEGF expression in dental pulp cells through ERK signalling

R. Khung et al.

INTERNATIONAL ENDODONTIC JOURNAL (2015)

Article Cell & Tissue Engineering

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

Bin Zhang et al.

STEM CELLS AND DEVELOPMENT (2014)

Article Dentistry, Oral Surgery & Medicine

Cold Plasma Therapy of a Tooth Root Canal Infected with Enterococcus faecalis Biofilms In Vitro

Jie Pan et al.

JOURNAL OF ENDODONTICS (2013)

Article Dentistry, Oral Surgery & Medicine

Antibacterial activity of dentine and pulp extracellular matrix extracts

J. G. Smith et al.

INTERNATIONAL ENDODONTIC JOURNAL (2012)

Article Dentistry, Oral Surgery & Medicine

Bactericidal effect of KTP laser irradiation against Enterococcus faecalis compared with gaseous ozone: an ex vivo study

Alper Kustarci et al.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY (2009)