Journal
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2021.768698
Keywords
surgical navigation; NIR-I; NIR-II; tumor; fluorescence imaging; image-guided cancer surgeries
Funding
- National Natural Science Foundation of China [21904035]
- China Postdoctoral Science Foundation [2020T130184]
- Hunan Provincial Natural Science Foundation of China [2020JJ5033]
- University of South China [201RGC012]
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Cancer remains a major global health concern despite advances in diagnostic and therapeutic technologies. Near-infrared (NIR) fluorescence plays a crucial role in image-guided cancer surgeries due to its tissue penetration, minimal scattering, and low autofluorescence. This review provides insights into the principles of fluorescence molecular imaging and the applications of NIR image-guided surgery in biomedical research, while also discussing current challenges and future directions in surgical navigation using fluorescence imaging.
Cancer is still one of the main causes of morbidity and death rate around the world, although diagnostic and therapeutic technologies are used to advance human disease treatment. Currently, surgical resection of solid tumors is the most effective and a prior remedial measure to treat cancer. Although medical treatment, technology, and science have advanced significantly, it is challenging to completely treat this lethal disease. Near-infrared (NIR) fluorescence, including the first near-infrared region (NIR-I, 650-900 nm) and the second near-infrared region (NIR-II, 1,000-1,700 nm), plays an important role in image-guided cancer surgeries due to its inherent advantages, such as great tissue penetration, minimal tissue absorption and emission light scattering, and low autofluorescence. By virtue of its high precision in identifying tumor tissue margins, there are growing number of NIR fluorescence-guided surgeries for various living animal models as well as patients in clinical therapy. Herein, this review introduces the basic construction and operation principles of fluorescence molecular imaging technology, and the representative application of NIR-I/II image-guided surgery in biomedical research studies are summarized. Ultimately, we discuss the present challenges and future perspectives in the field of fluorescence imaging for surgical navigation and also put forward our opinions on how to improve the efficiency of the surgical treatment.
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