Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.811196
Keywords
ferroptosis; pyroptosis; macrophage; vascular endothelial cells; vascular smooth muscle cells; atherosclerotic plaque
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Funding
- Innovation Team and Talent Support Program Project of National Administration of Traditional Chinese Medicine
- Youth Scholar Promotion Project of Chinese Society of China Association for Science and Technology
- Fundamental Research Funds for the Central Public Welfare Research Institutes [ZZ15-YQ-006]
- National Natural Science Foundation of China [81774141]
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Pyroptosis and ferroptosis play important roles in the development of atherosclerotic plaques, and may provide new strategies for treating atherosclerosis.
Pyroptosis is a special way of programmed cell death which is dependent on the activation of cysteinyl aspartate specific proteinase 1 (Caspase-1) and Caspase-4/5/11. Ferroptosis is an iron-dependent cell death that characterized by the intra-cellular lipid peroxidation-mediated membrane damage. Pyroptosis or ferroptosis in macrophages, smooth muscle cells, and vascular endothelial cells are believed to be closely related to the progression of atherosclerotic plaques. Therefore, we discuss the role of pyroptosis and ferroptosis in the development of atherosclerotic plaques and may provide new strategies for the treatment of atherosclerosis.
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