Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.813353
Keywords
Arf proteins; cargo sorting; vesicular trafficking; cargo adaptor; Arf GEF; Arf GAP
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Funding
- National Natural Science Foundation of China [NSFC31871421, NSFC32070699]
- Hong Kong Research Grants Council [16102921, 16102218, 16103319, 16104020, AoE/M-05/12, C4002-20W]
- Innovation and Technology Commission [ITCPD/17-9]
- Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [SMSEGL20SC01]
- Hong Kong PhD Fellowship Scheme (HKPFS)
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Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play crucial roles in cellular processes, particularly in regulating secretion and endocytic pathways. The proper activation and precise subcellular distribution of ARF family proteins, which are regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), are essential for the fidelity of intracellular vesicular trafficking. In this review, we summarize the recent progress in understanding the membrane recruitment, activation, crosstalk, and functions of ARF family proteins.
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways. The fidelity of intracellular vesicular trafficking depends on proper activations and precise subcellular distributions of ARF family proteins regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Here we review recent progress in understanding the membrane recruitment, activation, crosstalk, and functions of ARF family proteins.
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