4.7 Review

Meiotic Chromosome Dynamics in Zebrafish

Journal

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.757445

Keywords

zebrafish; meiosis; chromosome; recombination; synaptonemal complex; bouquet; telomeres

Funding

  1. JSPS KAKENHI [JP19K16045, JP18H06057, 25251034, 25114003, 19K22437, 21K06159]
  2. NIH [R01GM075119]
  3. Grants-in-Aid for Scientific Research [21K06159, 19K22437, 25251034] Funding Source: KAKEN

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Recent studies in zebrafish have provided insights on key features of meiotic chromosome dynamics, such as telomere clustering and homolog alignment. This review discusses the temporal progression of these events and the roles of proteins associated with homologous recombination.
Recent studies in zebrafish have revealed key features of meiotic chromosome dynamics, including clustering of telomeres in the bouquet configuration, biogenesis of chromosome axis structures, and the assembly and disassembly of the synaptonemal complex that aligns homologs end-to-end. The telomere bouquet stage is especially pronounced in zebrafish meiosis and sub-telomeric regions play key roles in mediating pairing and homologous recombination. In this review, we discuss the temporal progression of these events in meiosis prophase I and highlight the roles of proteins associated with meiotic chromosome architecture in homologous recombination. Finally, we discuss the interplay between meiotic mutants and gonadal sex differentiation and future research directions to study meiosis in living cells, including cell culture.

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