Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.753931
Keywords
degenerative musculoskeletal disorders; aging; age-related disease; non-coding RNAs; miRNA; circRNA; lncRNA
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Funding
- National Natural Science Foundation of China [81871844]
- Shanghai Education Development Foundation
- Shanghai Municipal Education Commission [18SG48]
- Shanghai Municipal Commission of Health and Family Planning [201840346]
- Shanghai Key Lab of Human Performance (Shanghai University of Sport) [11DZ2261100]
- Shanghai Frontiers Science Research Base of Exercise and Metabolic Health
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Musculoskeletal degenerative diseases (MSDDs) encompass a range of pathological conditions affecting muscle, bone, cartilage, joints, and connective tissues. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) play key roles in biological regulation and are potential targets for therapeutic interventions in MSDD. Further research is needed to uncover the mutual regulatory mechanisms between lncRNA/circRNA regulation and effective therapeutic interventions in MSDD pathology.
Musculoskeletal degenerative diseases (MSDDs) are pathological conditions that affect muscle, bone, cartilage, joint and connective tissue, leading to physical and functional impairments in patients, mainly consist of osteoarthritis (OA), intervertebral disc degeneration (IDD), rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are novel regulators of gene expression that play an important role in biological regulation, involving in chondrocyte proliferation and apoptosis, extracellular matrix degradation and peripheral blood mononuclear cell inflammation. Research on MSDD pathogenesis, especially on RA and AS, is still in its infancy and major knowledge gaps remain to be filled. The effects of lncRNA/circRNA-miRNA-mRNA axis on MSDD progression help us to fully understand their contribution to the dynamic cellular processes, provide the potential OA, IDD, RA and AS therapeutic strategies. Further studies are needed to explore the mutual regulatory mechanisms between lncRNA/circRNA regulation and effective therapeutic interventions in the pathology of MSDD.
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