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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Linking albinism and immunity: The secrets of secretory lysosomes
J Stinchcombe et al.
SCIENCE (2004)
The GGA proteins: key players in protein sorting at the trans-Golgi network
P Ghosh et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2004)
Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts
EL Eskelinen et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs
F Luciani et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2004)
The cytoplasmic tail of the cation-independent mannose 6-phosphate receptor contains four binding sites for AP-l
P Ghosh et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)
Melanocytes and the Microphthalmia transcription factor network
E Steingrimsson et al.
ANNUAL REVIEW OF GENETICS (2004)
Comprehensive search for cysteine cathepsins in the human genome
A Rossi et al.
BIOLOGICAL CHEMISTRY (2004)
Inactivation of the tuberous sclerosis complex-1 and-2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin
AR Tee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The chloride channel ClC-4 contributes to endosomal acidification and trafficking
R Mohammad-Panah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
K Inoki et al.
GENES & DEVELOPMENT (2003)
Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells
JK Jaiswal et al.
JOURNAL OF CELL BIOLOGY (2002)
Secretory lysosomes
EJ Blott et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I
DJ Katzmann et al.
CELL (2001)
Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus
XN Bi et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Specific retrieval of the exocytic SNARE Snc1p from early yeast endosomes
MJ Lewis et al.
MOLECULAR BIOLOGY OF THE CELL (2000)