Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.711815
Keywords
tumor microenvironment; m6A RNA modification; coding RNA; non-coding RNA; cancer
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Funding
- National Natural Science Foundation of China [81972663, U2004112]
- Key Scientific Research Projects of Institutions of Higher Education in Henan Province [19A310024]
- National Natural Science Foundation of Henan Province [182300410342]
- Health Commission Technology Talents Overseas Training Project of Henan Province [2018140]
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This review discusses the significant role of m6A RNA modifications in the tumor microenvironment, highlighting their potential as biomarkers and therapeutic targets for cancer therapy. Understanding the relationship between TME and m6A RNA modifications may lead to new approaches for future cancer treatment.
The tumor microenvironment (TME), which includes immune cells, fibroblasts, and other components, is the site of tumor cell growth and metastasis and significantly impacts tumor development. Among them, N6-methyladenosine RNA modifications (m6A RNA modifications) are the most abundant internal modifications in coding and non-coding RNAs, which can significantly influence the cancer process and have potential as biomarkers and potential therapeutic targets for tumor therapy. This manuscript reviews the role of m6A RNA modifications in TME and their application in tumor therapy. To some extent, an in-depth understanding of the relationship between TME and m6A RNA modifications will provide new approaches and ideas for future cancer therapy.
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