Metabolic Reprogramming and Cell Adhesion in Acute Leukemia Adaptation to the CNS Niche

Involvement of the Central Nervous System (CNS) in acute leukemia confers poor prognosis and lower overall survival. Existing CNS-directed therapies are associated with a significant risk of short- or long-term toxicities. Leukemic cells can metabolically adapt and survive in the microenvironment of the CNS. The supporting role of the CNS microenvironment in leukemia progression and dissemination has not received sufficient attention. Understanding the mechanism by which leukemic cells survive in the nutrient-poor and oxygen-deprived CNS microenvironment will lead to the development of more specific and less toxic therapies. Here, we review the current literature regarding the roles of metabolic reprogramming in leukemic cell adhesion and survival in the CNS.

Automated summary

Involvement of the Central Nervous System in acute leukemia is associated with poor prognosis and lower overall survival. Existing therapies pose significant toxicities. Leukemic cells can adapt and survive in the CNS microenvironment. Understanding the mechanisms of leukemic cell survival in the CNS microenvironment is crucial for developing more effective therapies.