4.7 Review

Regulation of Nuclear Factor-kappaB Function by O-GlcNAcylation in Inflammation and Cancer

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice

Xiaolong He et al.

Summary: O-GlcNAcylation, controlled by O-GlcNAcase and O-GlcNAc transferase, is an important post-translational modification of eukaryotic proteins involved in regulating gut inflammation. Gut microbiota encode enzymes involved in O-GlcNAcylation, with bacterial OGAs enriched in Bacteroidetes and Firmicutes. A metagenomic analysis across different diseases showed that bacterial OGA genes were conserved in healthy gut but reduced in ulcerative colitis. Studies demonstrated that bacterial OGAs can hydrolyse O-GlcNAcylated proteins in host cells, including NF kappa B-p65 subunit, and protect mice from colonic inflammation.
Article Biochemistry & Molecular Biology

Negative regulation of FOXP3 expression by c-Rel O-GlcNAcylation

Tristan J. de Jesus et al.

Summary: The study reveals that high glucose-induced O-GlcNAcylation negatively regulates FOXP3 expression through modulating c-Rel binding at the FOXP3 promoter, impacting immunosuppression and proautoimmune gene expression in autoimmune diabetes.

GLYCOBIOLOGY (2021)

Review Medicine, Research & Experimental

O-GlcNAcylation in immunity and inflammation: An intricate system (Review)

Yu Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

Article Biochemistry & Molecular Biology

Novel Targeted Nano-Parthenolide Molecule against NF-kB in Acute Myeloid Leukemia

Noureldien H. E. Darwish et al.

MOLECULES (2019)

Article Multidisciplinary Sciences

Blocked O-GlcNAc cycling disrupts mouse hematopoeitic stem cell maintenance and early T cell development

Lara K. Abramowitz et al.

SCIENTIFIC REPORTS (2019)

Article Nutrition & Dietetics

Augmented O-GlcNAcylation alleviates inflammation-mediated colon carcinogenesis via suppression of acute inflammation

Yoshimasa Hirata et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2018)

Article Medicine, Research & Experimental

O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis

Kekoa Taparra et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Oncology

Hexosamine Biosynthetic Pathway Inhibition Leads to AML Cell Differentiation and Cell Death

Abhishek Asthana et al.

MOLECULAR CANCER THERAPEUTICS (2018)

Review Medicine, Research & Experimental

The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy

Fatima Ardito et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Article Immunology

Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival

Casey D. S. Katerndahl et al.

NATURE IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

NF-κB in Hematological Malignancies

Veronique Imbert et al.

BIOMEDICINES (2017)

Review Oncology

c-Rel and its many roles in cancer: an old story with new twists

Jill E. Hunter et al.

BRITISH JOURNAL OF CANCER (2016)

Review Biochemistry & Molecular Biology

O-GIcNAcylation in Cancer Biology: Linking Metabolism and Signaling

Christina M. Ferrer et al.

JOURNAL OF MOLECULAR BIOLOGY (2016)

Review Biochemistry & Molecular Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Review Cell Biology

The Regulation of NF-κB Subunits by Phosphorylation

Frank Christian et al.

CELLS (2016)

Review Oncology

NF-κB: Regulation by Methylation

Tao Lu et al.

CANCER RESEARCH (2015)

Editorial Material Oncology

CCR 20th Anniversary Commentary: In the Beginning, There Was PS-341

Beverly A. Teicher et al.

CLINICAL CANCER RESEARCH (2015)

Review Biochemistry & Molecular Biology

Cancer Metabolism and Elevated O-GlcNAc in Oncogenic Signaling

Zhiyuan Ma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Oncology

NF-κB, an Active Player in Human Cancers

Yifeng Xia et al.

CANCER IMMUNOLOGY RESEARCH (2014)

Article Pharmacology & Pharmacy

O-GlcNAcylation and p50/p105 binding of c-Rel are dynamically regulated by LPS and glucosamine in BV2 microglia cells

So-Young Hwang et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Article Biochemistry & Molecular Biology

Epigenetic Switching by the Metabolism-sensing Factors in the Generation of Orexin Neurons from Mouse Embryonic Stem Cells

Koji Hayakawa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells

Zhiyuan Ma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Activation of the Transcriptional Function of the NF-κB Protein c-Rel by O-GlcNAc Glycosylation

Parameswaran Ramakrishnan et al.

SCIENCE SIGNALING (2013)

Article Biochemistry & Molecular Biology

Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition

Ludivine Drougat et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)

Article Medicine, Research & Experimental

Gene expression of O-GlcNAc cycling enzymes in human breast cancers

Anna Krzeslak et al.

CLINICAL AND EXPERIMENTAL MEDICINE (2012)

Article Biochemistry & Molecular Biology

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

Shalini Pathak et al.

EMBO JOURNAL (2012)

Article Biochemistry & Molecular Biology

Critical Role of O-Linked β-N-Acetylglucosamine Transferase in Prostate Cancer Invasion, Angiogenesis, and Metastasis

Thomas P. Lynch et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription

David F. Allison et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Biochemistry & Molecular Biology

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

Gerald W. Hart et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)

Article Biochemistry & Molecular Biology

O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy

Wenyi Mi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)

Review Cell Biology

NF-κB in immunobiology

Matthew S. Hayden et al.

CELL RESEARCH (2011)

Article Biochemistry & Molecular Biology

Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing

Dorothee Pflueger et al.

GENOME RESEARCH (2011)

Article Radiology, Nuclear Medicine & Medical Imaging

Role of Glutamine in Cancer: Therapeutic and Imaging Implications

Kartik N. Rajagopalan et al.

JOURNAL OF NUCLEAR MEDICINE (2011)

Review Biochemistry & Molecular Biology

The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine

John A. Hanover et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2010)

Article Oncology

Requirement of the NF-κB Subunit p65/RelA for K-Ras-Induced Lung Tumorigenesis

Daniela S. Basseres et al.

CANCER RESEARCH (2010)

Article Biochemistry & Molecular Biology

Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Cytokinesis

Zihao Wang et al.

SCIENCE SIGNALING (2010)

Article Cardiac & Cardiovascular Systems

Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-κB signaling

Luyun Zou et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)

News Item Biochemistry & Molecular Biology

NF-κB: A Key Player in Lung Cancer

[Anonymous]

Article Multidisciplinary Sciences

Loss of p53 enhances catalytic activity of IKKβ through O-linked β-N-acetyl glucosamine modification

Keiko Kawauchi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma

Etienne Meylan et al.

NATURE (2009)

Article Multidisciplinary Sciences

NFκB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions

Won Ho Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Cross-talk between GlcNAcylation and phosphorylation:: Site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc

Zihao Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation

Alexander Golks et al.

EMBO JOURNAL (2007)

Article Biochemical Research Methods

Dynamic interplay between O-linked N-acetylglucosaminylation and glycogen synthase kinase-3-dependent phosphorylation

Zihao Wang et al.

MOLECULAR & CELLULAR PROTEOMICS (2007)

Review Multidisciplinary Sciences

Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins

Gerald W. Hart et al.

NATURE (2007)

Article Multidisciplinary Sciences

NF-κB functions as a tumour promoter in inflammation-associated cancer

E Pikarsky et al.

NATURE (2004)

Article Multidisciplinary Sciences

O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease

F Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression

R Bichi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Review Oncology

NF-κB in cancer:: From innocent bystander to major culprit

M Karin et al.

NATURE REVIEWS CANCER (2002)

Review Pathology

New insights into the role of nuclear factor-κB in cell growth regulation

F Chen et al.

AMERICAN JOURNAL OF PATHOLOGY (2001)

Article Multidisciplinary Sciences

The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny

R Shafi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)