Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.770705
Keywords
bone marrow adipocytes; bone marrow mesenchymal stromal cells; hematopoiesis; osteogenesis; osteoclastogenesis; immune regulation
Categories
Funding
- National Key Research and Development Plan [2018YFC2001500]
- National Natural Science Foundation of China (NSFC) Key Research Program in Aging [91749204]
- National Natural Science Foundation of China [81771491, 81871099, 81972254, 82172098]
- Shanghai Rising-Star Program [21QA1412000]
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BMAs, as a type of bone marrow adipocytes, play significant roles in hematopoiesis, osteogenesis, and immune regulation, and represent a novel target for the treatment of bone marrow-related diseases.
Recognized for nearly 100 years, bone marrow adipocytes (BMAs) form bone marrow niches that contain hematopoietic and bone cells, the roles of which have long been underestimated. Distinct from canonical white, brown, and beige adipocytes, BMAs derived from bone marrow mesenchymal stromal cells possess unique characteristics and functions. Recent single-cell sequencing studies have revealed the differentiation pathway, and seminal works support the tenet that BMAs are critical regulators in hematopoiesis, osteogenesis, and osteoclastogenesis. In this review, we discuss the origin and differentiation of BMAs, as well as the roles of BMAs in hematopoiesis, osteogenesis, osteoclastogenesis, and immune regulation. Overall, BMAs represent a novel target for bone marrow-related diseases, including osteoporosis and leukemia.
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