Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.770931
Keywords
heterotopic ossification; mechanical loading; bone; stem cell fate; bone formation
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Funding
- National Key R&D Program of China [2019YFA0111900]
- National Natural Science Foundation of China [81922017, 81873669, 81802209]
- Hunan Province Natural Science Foundation of China [2018JJ3863]
- Hunan Provincial Science and Technology Department [2018RS3030]
- Innovation Driven Project of Central South University [20170033010017]
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In this article, the primary characteristics of heterotopic ossification are reviewed from both clinical and basic research perspectives, with a special highlight on the influence of mechanics on heterotopic ossification, which serves an important role in the prophylaxis and treatment of HO.
Heterotopic ossification (HO) is defined as the occurrence of extraskeletal bone in soft tissue. Although this pathological osteogenesis process involves the participation of osteoblasts and osteoclasts during the formation of bone structures, it differs from normal physiological osteogenesis in many features. In this article, the primary characteristics of heterotopic ossification are reviewed from both clinical and basic research perspectives, with a special highlight on the influence of mechanics on heterotopic ossification, which serves an important role in the prophylaxis and treatment of HO.
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