4.7 Article

Estrogen Attenuates Chronic Stress-Induced Cardiomyopathy by Adaptively Regulating Macrophage Polarizations via β2-Adrenergic Receptor Modulation

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Estrogen Protects Vasomotor Functions in Rats During Catecholamine Stress

Lin Zhang et al.

Summary: The study aimed to investigate the impact of estrogen deficiency during catecholamine stress on vasomotor function, as well as to utilize estrogen replacement therapy to mitigate the adverse effects of stress on aortic vessels. The results showed that estrogen prevented excessive weight gain during stress, while upregulating eNOS activities and decreasing ET-1 expressions to facilitate vasomotor functions. Overall, estrogen treatments during stress preserved vasomotor functions by preventing excessive intima-media thickening and collagen depositions in the aortic vascular walls.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Review Cardiac & Cardiovascular Systems

Sex-Gender Disparities in Cardiovascular Diseases: The Effects of Estrogen on eNOS, Lipid Profile, and NFATs During Catecholamine Stress

Marie Louise Ndzie Noah et al.

Summary: Based on research in recent decades, estrogen plays an important role in modulating cardioprotective and immunoregulatory effects, with crucial implications for explaining sex differences in cardiovascular diseases. Estrogen decreases the incidence of hypertension, coronary heart disease, and pathological cardiac hypertrophy in premenopausal women by regulating cardiac stimuli signals.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Pharmacology & Pharmacy

α7-nAChRs-mediated therapeutic angiogenesis accounts for the advantageous effect of low nicotine doses against myocardial infarction in rats

Mahmoud E. Youssef et al.

Summary: α7-nicotinic acetylcholine receptor-induced angiogenesis alleviates pathological and electrocardiographic signs of myocardial infarction in rats, suggesting a promising therapeutic strategy for ischemic conditions.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Catalpol Inhibits Macrophage Polarization and Prevents Postmenopausal Atherosclerosis Through Regulating Estrogen Receptor Alpha

Qi Chen et al.

Summary: The study showed that catalpol significantly inhibited macrophage polarization and prevented postmenopausal AS by increasing ER alpha expression.

FRONTIERS IN PHARMACOLOGY (2021)

Article Cell Biology

Cardiac GRK2 Protein Levels Show Sexual Dimorphism during Aging and Are Regulated by Ovarian Hormones

Alba C. Arcones et al.

Summary: A clear sexual dimorphism in cardiovascular disease (CVD) risk is observed, with young women having a lower incidence compared to age-matched men, but this protection is lost after menopause. Changes in G protein-coupled receptor kinase 2 (GRK2) protein levels in the heart are linked to age-related sensitivity to CVD development, with ovarian hormones playing a role in regulating GRK2 levels in the cardiac muscle, contributing to the sex-dependent dynamics of CVD risk.

CELLS (2021)

Article Endocrinology & Metabolism

DPP-4 Inhibitors Have Different Effects on Endothelial Low-Grade Inflammation and on the M1-M2 Macrophage Polarization Under Hyperglycemic Conditions

Valeria De Nigris et al.

Summary: The study found that teneligliptin, but not sitagliptin, has anti-inflammatory effects in various low-grade inflammation models, promoting a switch from M1 to M2 phenotype in macrophages and reducing hyperglycemia-induced endothelial inflammation.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2021)

Review Obstetrics & Gynecology

A Systematic Review of Palpitations Prevalence by Menopausal Status

Janet S. Carpenter et al.

Summary: The systematic review aimed to examine the prevalence of palpitations by menopausal stage. Findings from five articles across different countries showed that perimenopausal and surgically postmenopausal women had significantly higher palpitation prevalence compared to premenopausal and postmenopausal women. The varying measurement methods of palpitations prevalence suggest a need for standardization in assessment.

CURRENT OBSTETRICS AND GYNECOLOGY REPORTS (2021)

Article Endocrinology & Metabolism

17β-Estradiol Inhibits PCSK9-Mediated LDLR Degradation Through GPER/PLC Activation in HepG2 Cells

Wei Fu et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Myocardial and Systemic Inflammation in Acute Stress-Induced (Takotsubo) Cardiomyopathy

Caroline Scally et al.

CIRCULATION (2019)

Article Cell Biology

Neonatal cardiomyocyte hypertrophy induced by endothelin-1 is blocked by estradiol acting on GPER

Gleisy Kelly Goncalves et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Mapping macrophage polarization over the myocardial infarction time continuum

Alan J. Mouton et al.

BASIC RESEARCH IN CARDIOLOGY (2018)

Article Immunology

Cardiac macrophages promote diastolic dysfunction

Maarten Hulsmans et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Article Physiology

Estrogen deficiency compromised the β2AR-Gs/Gi coupling: implications for arrhythmia and cardiac injury

Hongjian Hou et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Characterization of the Myocardial Inflammatory Response in Acute Stress-Induced (Takotsubo) Cardiomyopathy

Heather M. Wilson et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2018)

Article Medicine, Research & Experimental

Identification of different macrophage subpopulations with distinct activities in a mouse model of oxygen-induced retinopathy

Yanji Zhu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Article Immunology

Estrogen Signaling Contributes to Sex Differences in Macrophage Polarization during Asthma

Aleksander Keselman et al.

JOURNAL OF IMMUNOLOGY (2017)

Review Cardiac & Cardiovascular Systems

Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease

Austin C. Boese et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Estrogen resisted stress-induced cardiomyopathy through increasing the activity of β2AR-Gαs signal pathway in female rats

Xiancun Cao et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)

Article Multidisciplinary Sciences

Estrogen accelerates the resolution of inflammation in macrophagic cells

Alessandro Villa et al.

SCIENTIFIC REPORTS (2015)

Article Cell & Tissue Engineering

Mesenchymal Stem Cells and Cardiomyocytes Interplay to Prevent Myocardial Hypertrophy

Benzhi Cai et al.

STEM CELLS TRANSLATIONAL MEDICINE (2015)

Article Cardiac & Cardiovascular Systems

Systolic and Diastolic Mechanics in Stress Cardiomyopathy

Keith Medeiros et al.

CIRCULATION (2014)

Article Dermatology

Estrogen Receptor-Alpha Promotes Alternative Macrophage Activation during Cutaneous Repair

Laura Campbell et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

Article Multidisciplinary Sciences

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

Kory J. Lavine et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Sex differences in cardiovascular function during submaximal exercise in humans

Courtney M. Wheatley et al.

SPRINGERPLUS (2014)

Article Hematology

Macrophage Function and Polarization in Cardiovascular Disease A Role of Estrogen Signaling?

Chiara Bolego et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

Article Multidisciplinary Sciences

Carvedilol Prevents Ovariectomy-Induced Myocardial Contractile Dysfunction in Female Rat

Rogerio Faustino Ribeiro et al.

PLOS ONE (2013)

Article Endocrinology & Metabolism

Testosterone enhances estradiol's cardioprotection in ovariectomized rats

Aiying Liu et al.

JOURNAL OF ENDOCRINOLOGY (2012)

Article Multidisciplinary Sciences

Isolation of Mouse Peritoneal Cavity Cells

Avijit Ray et al.

Jove-Journal of Visualized Experiments (2010)

Article Hematology

Estrogen and Mechanisms of Vascular Protection

Dongqi Xing et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)

Article Obstetrics & Gynecology

Progesterone stimulates cardiac muscle protein synthesis via receptor-dependent pathway

J Goldstein et al.

FERTILITY AND STERILITY (2004)

Article Cardiac & Cardiovascular Systems

Impact of estrogen replacement on ventricular myocyte contractile function and protein kinase B/Akt activation

J Ren et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)