4.7 Review

The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis

Loretah Chibaya et al.

Summary: The phosphorylation of Mdm2 by Akt was found to reduce p53 levels and prevent senescence in cells exposed to oxidative stress. This resulted in the promotion of lung cancers driven by Kras(G12D) and carcinogen-induced papilloma and hepatocellular carcinomas in mouse models of ROS-induced cancer. These findings highlight a unique physiological role for Akt-Mdm2-p53 signaling in regulating cell growth and tumorigenesis in response to oxidative stress.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Cell Biology

FBXW7 Confers Radiation Survival by Targeting p53 for Degradation

Danrui Cui et al.

CELL REPORTS (2020)

Article Multidisciplinary Sciences

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

David E. Gordon et al.

NATURE (2020)

Review Genetics & Heredity

Regulation of mTORC2 Signaling

Wenxiang Fu et al.

GENES (2020)

Article Cell Biology

DEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity

Danrui Cui et al.

CELL DEATH & DISEASE (2020)

Article Multidisciplinary Sciences

The 3.2-Å resolution structure of human mTORC2

Alain Scaiola et al.

SCIENCE ADVANCES (2020)

Review Cell Biology

The multiple mechanisms that regulate p53 activity and cell fate

Antonina Hafner et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

SCF(FBXW7)-mediated degradation of p53 promotes cell recovery after UV-induced DNA damage

Maria Galindo-Moreno et al.

FASEB JOURNAL (2019)

Article Biochemistry & Molecular Biology

Abrogation of FBW7α-dependent p53 degradation enhances p53's function as a tumor suppressor

Vivek Tripathi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

Seung Hee Jung et al.

ONCOGENE (2019)

Article Biochemistry & Molecular Biology

MicroRNA Control of p53

Juan Liu et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

Review Biochemistry & Molecular Biology

Census and evaluation of p53 target genes

M. Fischer

ONCOGENE (2017)

Review Biochemistry & Molecular Biology

Emerging Role of MicroRNAs in mTOR Signaling

Yanjie Zhang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth, Metabolism, and Disease

Robert A. Saxton et al.

Article Multidisciplinary Sciences

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1

Yue Ma-Lauer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Medical Laboratory Technology

Mechanisms of p53 degradation

Chuck C. -K. Chao

CLINICA CHIMICA ACTA (2015)

Review Biochemistry & Molecular Biology

The role of ubiquitin modification in the regulation of p53

Andreas K. Hock et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

Review Biochemistry & Molecular Biology

The cytoplasmic side of p53′s oncosuppressive activities

Anna Comel et al.

FEBS LETTERS (2014)

Article Gastroenterology & Hepatology

EEF1A2 Inactivates p53 by Way of PI3K/AKT/mTOR-Dependent Stabilization of MDM4 in Hepatocellular Carcinoma

Rossella Pellegrino et al.

HEPATOLOGY (2014)

Article Biochemistry & Molecular Biology

Effect of microRNA-101 on proliferation and apoptosis of human osteosarcoma cells by targeting mTOR

Song Lin et al.

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES (2014)

Review Cell Biology

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Peter E. Czabotar et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Editorial Material Oncology

Dual PI3K/mTOR Inhibitors: Does p53 Modulate Response?

Oleksandr Ekshyyan et al.

CLINICAL CANCER RESEARCH (2013)

Article Oncology

miRNA-100 Inhibits Human Bladder Urothelial Carcinogenesis by Directly Targeting mTOR

Chuanliang Xu et al.

MOLECULAR CANCER THERAPEUTICS (2013)

Article Oncology

miRNA-101: A potential target for tumor therapy

Ting Gui et al.

CANCER EPIDEMIOLOGY (2012)

Article Cell & Tissue Engineering

p53-Facilitated miR-199a-3p Regulates Somatic Cell Reprogramming

Jiaxu Wang et al.

STEM CELLS (2012)

Review Oncology

MicroRNAs in the p53 network: micromanagement of tumour suppression

Heiko Hermeking

NATURE REVIEWS CANCER (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Oncology

The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis

Sadegh Babashah et al.

EUROPEAN JOURNAL OF CANCER (2011)

Article Cell Biology

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim et al.

NATURE CELL BIOLOGY (2011)

Article Multidisciplinary Sciences

MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma

Lei Jin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Oncology

Role of p53 in Cell Death and Human Cancers

Toshinori Ozaki et al.

Cancers (2011)

Article Biochemistry & Molecular Biology

Structural Analysis and Functional Implications of the Negative mTORCl Regulator REDD1

Silvia Vega-Rubin-de-Celis et al.

BIOCHEMISTRY (2010)

Article Biochemistry & Molecular Biology

MicroRNA: Biogenesis, Function and Role in Cancer

Leigh-Ann MacFarlane et al.

CURRENT GENOMICS (2010)

Article Biochemistry & Molecular Biology

S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

Keng Po Lai et al.

EMBO JOURNAL (2010)

Review Biochemistry & Molecular Biology

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

Shomit Sengupta et al.

MOLECULAR CELL (2010)

Article Biochemistry & Molecular Biology

MdmX is a substrate for the deubiquitinating enzyme USP2a

N. Allende-Vega et al.

ONCOGENE (2010)

Article Biochemistry & Molecular Biology

The mitochondrial p53 pathway

Angelina V. Vaseva et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2009)

Review Biochemistry & Molecular Biology

Blinded by the Light: The Growing Complexity of p53

Karen H. Vousden et al.

Review Biochemistry & Molecular Biology

Modes of p53 Regulation

Jan-Philipp Kruse et al.

Article Genetics & Heredity

Common mechanisms of PIKK regulation

Courtney A. Lovejoy et al.

DNA REPAIR (2009)

Article Multidisciplinary Sciences

Modulation of microRNA processing by p53

Hiroshi I. Suzuki et al.

NATURE (2009)

Article Multidisciplinary Sciences

p53 represses c-Myc through induction of the tumor suppressor miR-145

Mohit Sachdeva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Cell Biology

A dual role of p53 in the control of autophagy

Ezgi Tasdemir et al.

AUTOPHAGY (2008)

Article Biochemistry & Molecular Biology

p53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling

Andrei V. Budanov et al.

Article Cell Biology

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

Maurice Phillip DeYoung et al.

GENES & DEVELOPMENT (2008)

Article Biochemistry & Molecular Biology

Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding

Vanessa Lopez-Pajares et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

AMPK phosphorylation of raptor mediates a metabolic checkpoint

Dana M. Gwinn et al.

MOLECULAR CELL (2008)

Article Cell Biology

Regulation of autophagy by cytoplasmic p53

Ezgi Tasdemir et al.

NATURE CELL BIOLOGY (2008)

Article Multidisciplinary Sciences

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Yasemin Sancak et al.

SCIENCE (2008)

Article Biochemistry & Molecular Biology

Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1

M. Chiara Maiuri et al.

EMBO JOURNAL (2007)

Article Biochemistry & Molecular Biology

Ribosomal protein S27L is a direct p53 target that regulates apoptosis

H. He et al.

ONCOGENE (2007)

Article Biochemistry & Molecular Biology

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

Yasemin Sancak et al.

MOLECULAR CELL (2007)

Article Cell Biology

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

Emilie Vander Haar et al.

NATURE CELL BIOLOGY (2007)

Article Developmental Biology

Met acts on Mdm2 via mTOR to signal cell survival during development

Anice Moumen et al.

DEVELOPMENT (2007)

Article Biochemistry & Molecular Biology

Endoplasmic reticulum stress triggers autophagy

Tomohiro Yorimitsu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

Diane Crighton et al.

Article Biochemistry & Molecular Biology

Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3β

O Pluquet et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

XM Long et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

RG Jones et al.

MOLECULAR CELL (2005)

Article Multidisciplinary Sciences

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

PP Roux et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

JH Feng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Cell Biology

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

LS Harrington et al.

JOURNAL OF CELL BIOLOGY (2004)

Article Multidisciplinary Sciences

The PP2A-associated protein α4 is an essential inhibitor of apoptosis

M Kong et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals

ZQ Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

AV Budanov et al.

ONCOGENE (2002)

Article Cell Biology

Akt regulates growth by directly phosphorylating Tsc2

CJ Potter et al.

NATURE CELL BIOLOGY (2002)

Article Cell Biology

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

K Inoki et al.

NATURE CELL BIOLOGY (2002)

Article Biochemistry & Molecular Biology

PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy

LD Mayo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Cell Biology

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

BHP Zhou et al.

NATURE CELL BIOLOGY (2001)

Article Multidisciplinary Sciences

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

LD Mayo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

PUMA, a novel proapoptotic gene, is induced by p53

K Nakano et al.

MOLECULAR CELL (2001)