4.7 Article

Irreversible depletion of intestinal CD4+ T cells is associated with T cell activation during chronic HIV infection

Journal

JCI INSIGHT
Volume 6, Issue 22, Pages -

Publisher

AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/jci.insight.146162

Keywords

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Funding

  1. Wellcome Trust [202485/Z/16/Z, 210662/Z/18/Z, 107752/Z/15/Z]
  2. National Institute of Health (NIH) [R01DK126545]
  3. Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE) , a DELTAS Africa Initia-tive [DEL-15-006]
  4. New Partnership for Africa's Development Planning and Coordinating Agency (NEPAD Agency)
  5. United Kingdom government
  6. Wellcome Trust [210662/Z/18/Z, 202485/Z/16/Z] Funding Source: Wellcome Trust

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Research conducted on a large cohort recruited from high HIV endemic areas in South Africa revealed that people living with HIV presented at a younger age for GI clinic investigation, with severe CD4(+) T cell depletion in the GI tract, particularly in the colon. Despite full suppression of plasma viremia, HIV-p24 staining showed persistent viral expression, emphasizing the irreversible loss of GI CD4(+) T cells as a key event in HIV pathogenesis in PLWH in South Africa.
HIV infection in the human gastrointestinal (GI) tract is thought to be central to HIV progression, but knowledge of this interaction is primarily limited to cohorts within Westernized countries. Here, we present a large cohort recruited from high HIV endemic areas in South Africa and found that people living with HIV (PLWH) presented at a younger age for investigation in the GI clinic. We identified severe CD4(+) T cell depletion in the GI tract, which was greater in the small intestine than in the large intestine and not correlated with years on antiretroviral treatment (ART) or plasma viremia. HIV-p24 staining showed persistent viral expression, particularly in the colon, despite full suppression of plasma viremia. Quantification of mucosal antiretroviral (ARV) drugs revealed no differences in drug penetration between the duodenum and colon. Plasma markers of gut barrier breakdown and immune activation were elevated irrespective of HIV, but peripheral T cell activation was inversely correlated with loss of gut CD4(+) T cells in PLWH alone. T cell activation is a strong predictor of HIV progression and independent of plasma viral load, implying that the irreversible loss of GI CD4(+) T cells is a key event in the HIV pathogenesis of PLWH in South Africa, yet the underlying mechanisms remain unknown.

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