Journal
APPLIED MATERIALS TODAY
Volume 25, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.apmt.2021.101183
Keywords
Supported lipid bilayer; Diagnostic; Bicelle; Vesicle fusion; Solvent-assisted lipid bilayer
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Funding
- National Research Foundation of Singapore through a Proof-of-Concept grant [NRF2015NRF-POC0001-19]
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [2020R1C1C1004385, 2020R1C1C1005523]
- Brain Pool Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2019H1D3A1A01070318]
- National Research Foundation of Korea [2020R1C1C1005523] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Supported lipid bilayer (SLB) coatings, versatile cell-membrane-mimicking biointerfaces, have been expanded for medical and biotechnology applications, facilitating various studies and applications like biosensors, diagnostics, and antifouling surfaces.
Supported lipid bilayer (SLB) coatings are versatile, cell-membrane-mimicking biointerfaces that are useful for fundamental biophysical studies and for various applications such as biosensors, diagnostics, and antifouling surfaces. However, until recently, SLB research was mainly limited to niche interfacial science research communities and ongoing material science advances have expanded the fabrication ease, scalability, and utility of SLB platforms for medical and biotechnology applications. Herein, we critically discuss ongoing progress in SLB fabrication, bioconjugation, and diagnostic applications, with particular focus on clinical-stage circulating tumor cell (CTC) detection for cancer diagnosis. A comprehensive overview of conventional and emerging SLB fabrication methods is provided along with different bioconjugation strategies to attach biomacromolecules such as proteins to SLB surfaces for molecular recognition purposes. We then examine how antibody-functionalized SLB platforms are being utilized for CTC detection and introduce clinical application examples. Future trends and application possibilities are also projected and demonstrate how SLB coatings are evolving into a robust surface functionalization option for endowing sensor surfaces with biomimetic functionalities. (c) 2021 Elsevier Ltd. All rights reserved.
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