Journal
APPLIED MATERIALS TODAY
Volume 25, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.apmt.2021.101194
Keywords
Bioceramics; Well ordered-microstructure; Mechanical performances; Biological performances
Categories
Funding
- National Key Research and De-velopment Program of China [2018YFC1105201]
- National Natural Science Foundation of China [32130 0 0574]
- Innovation Cross Team of Chinese Academy of Sciences [JCTD-2018-13]
- Science and Technology Commission of Shanghai Municipality [20442420300, 21DZ1205600]
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The study introduces a universal biomineralization-assembly-sintering approach for the fabrication of well ordered microstructure meta-hydroxyapatite, inspired by high-performance natural composites. The material demonstrates remarkable mechanical performances matching that of human cortical bone, playing a significant role in stimulating bone defects regeneration in vivo.
It is a great challenge to endow the bioceramics with the bone-matched mechanical performances. Here, capturing inspiration from well ordered-microstructures in the high-performance natural composites, we propose a universal biomineralization-assembly-sintering approach for the fabrication of well ordered microstructure meta-hydroxyapatite. Owing to the well ordered-microstructure and a new metal ions related interface toughening mechanism, this well ordered-microstructure hydroxyapatite exhibits remarkable mechanical performances, which are far beyond those of existing hydroxyapatite-based bioceramic and totally matched with the human cortical bone. Furthermore, the ordered microstructure plays a significant role in modulating the cell fates and finally stimulating bone defects regeneration in vivo . This work not only provides a strategy for the fabrication of well ordered-microstructure bioceramic but also broadens the horizons for the interface toughening mechanism of composites and microstructure design of biomaterials for bone regeneration. (c) 2021 Elsevier Ltd. All rights reserved.
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