Journal
JOURNAL OF EXTRACELLULAR VESICLES
Volume 10, Issue 14, Pages -Publisher
WILEY
DOI: 10.1002/jev2.12144
Keywords
ectosome; exosome; extracellular vesicle; microparticle; microvesicle
Categories
Funding
- BBSRC [BB/P006205/1]
- Cancer Research UK [A28052]
- Alzheimer's Research UK [ARUK-RF2019B-004]
- NIH/NCI [R01CA234557, R01CA218526, AI144997, DA047807, MH118164, CA241694]
- Michael J. Fox Foundation
- Scar Free Foundation
- National Institute for Health Research (NIHR) Surgical Reconstruction and Microbiology Research Centre (SRMRC)
- BBSRC [BB/P006205/1] Funding Source: UKRI
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Extracellular vesicles (EVs) are small cargo-bearing vesicles released by cells into the extracellular space, serving as a complex cell-to-cell communication mechanism that transfers functional cargo and influences biological processes, with deregulation in disease. The field of EVs has grown exponentially over the past two decades with an organized community, but still faces key challenges.
Extracellular vesicles (EVs) are small cargo-bearing vesicles released by cells into the extracellular space. The field of EVs has grown exponentially over the past two decades; this growth follows the realisation that EVs are not simply a waste disposal system as had originally been suggested by some, but also a complex cell-to-cell communication mechanism. Indeed, EVs have been shown to transfer functional cargo between cells and can influence several biological processes. These small biological particles are also deregulated in disease. As we approach the 75th anniversary of the first experiments in which EVs were unknowingly isolated, it seems right to take stock and look back on how the field started, and has since exploded into its current state. Here we review the early experiments, summarise key findings that have propelled the field, describe the growth of an organised EV community, discuss the current state of the field, and identify key challenges that need to be addressed.
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