Journal
JOURNAL OF EXTRACELLULAR VESICLES
Volume 11, Issue 1, Pages -Publisher
WILEY
DOI: 10.1002/jev2.12151
Keywords
exosomes; extracellular vesicles; in vivo; microvesicles; pathology; physiology
Categories
Funding
- Nathalie Rose-BarrAward [NRB2015]
- Academy of Finland [330486]
- Business Finland (EVE consortium)
- British Heart Foundation the Centre of Research Excellence [RE/13/1/30181]
- British Heart Foundation [PG/18/53/33895]
- Novo Nordisk Foundation [NNF15CC0018486]
- National Institute for Health Research (NIHR)
- Oxford Biomedical Research Centre (BRC)
- Nuffield Benefaction for Medicine
- Wellcome Institutional Strategic Support Fund (ISSF)
- Royal Society [RG150218]
- Jannsen Pharamaceuticals
- GPADD
- Associacao Beneficente Alzira Denise Hertzog Silva (ABADHS)
- Conselho Nacional de Desenvolvimen to Cientifico eTecnologico (CNPq)
- Fundacao de Amparoa Pesquisado Estado de SaoPaulo (FAPESP) [11/09172-3, 15/50257-3, 14/26897-0]
- Rosetrees Trust Foundation [M279]
- Alzheimer's Research UK [ARUK-RF2019B-004]
- Tripartite Immunometabolism Consortium
- British Heart Foundation [PG/18/53/33895] Funding Source: researchfish
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [11/09172-3] Funding Source: FAPESP
- Academy of Finland (AKA) [330486, 330486] Funding Source: Academy of Finland (AKA)
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Previously considered cellular debris, extracellular vesicles (EVs) are now recognized as mediators of physiological and pathological functions in the body. They have the ability to transfer nucleic acids and proteins between distant organs, interact with target cells through their surface proteins, and play a role in health and disease through vesicle-bound lipids. EVs are crucial in the pathogenesis of diseases and the maintenance of system and organ homeostasis.
Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are now known to mediate physiological and pathological functions throughout the body. We now understand more about their capacity to transfer nucleic acids and proteins between distant organs, the interaction of their surface proteins with target cells, and the role of vesicle-bound lipids in health and disease. To date, most observations have been made in reductionist cell culture systems, or as snapshots from patient cohorts. The heterogenous population of vesicles produced in vivo likely act in concert to mediate both beneficial and detrimental effects. EVs play crucial roles in both the pathogenesis of diseases, from cancer to neurodegenerative disease, as well as in the maintenance of system and organ homeostasis. This two-part review draws on the expertise of researchers working in the field of EV biology and aims to cover the functional role of EVs in physiology and pathology. Part I will outline the role of EVs in normal physiology.
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