Journal
NATURE REVIEWS CHEMISTRY
Volume 5, Issue 11, Pages 792-815Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41570-021-00324-y
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Funding
- Fonds der Chemischen Industrie
- Boehringer Ingelheim Foundation
- Alexander von Humboldt Foundation
- Max Planck Society
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Non-covalent interactions are essential in bond-forming events, particularly in the realm of synthetic carbohydrate chemistry. The exploitation of NCIs has led to advancements in catalyzed glycosylations, glycofunctionalizations, and stabilization of intermediates. Additionally, emerging opportunities in utilizing halogen bonding and unconventional NCIs have shown promise in various aspects of carbohydrate chemistry.
Non-covalent interactions (NCIs) are a vital component of biological bond-forming events, and have found important applications in multiple branches of chemistry. In recent years, the biomimetic exploitation of NCIs in challenging glycosidic bond formation and glycofunctionalizations has attracted significant interest across diverse communities of organic and carbohydrate chemists. This emerging theme is a major new direction in contemporary carbohydrate chemistry, and is rapidly gaining traction as a robust strategy to tackle long-standing issues such as anomeric and site selectivity. This Review thus seeks to provide a bird's-eye view of wide-ranging advances in harnessing NCIs within the broad field of synthetic carbohydrate chemistry. These include the exploitation of NCIs in non-covalent catalysed glycosylations, in non-covalent catalysed glycofunctionalizations, in aglycone delivery, in stabilization of intermediates and transition states, in the existence of intramolecular hydrogen bonding networks and in aggregation by hydrogen bonds. In addition, recent emerging opportunities in exploiting halogen bonding and other unconventional NCIs, such as CH-pi, cation-pi and cation-n interactions, in various aspects of carbohydrate chemistry are also examined.
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