Journal
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
Volume 52, Issue 1, Pages 171-179Publisher
WILEY
DOI: 10.1111/ijfs.13263
Keywords
Banana flower; glycation; Maillard reaction; Musa spp; phytosterol; alpha-amylase; alpha-glucosidase
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Funding
- National Natural Science Foundation of China [31201303]
- China Scholarship Council Visiting Scholar Program [201403260010]
- Louisiana State University Agricultural Center, USA
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Three phytosterols were isolated from Musa spp. flowers for evaluating their capabilities in inhibiting glucosidase and amylase activities and glycation of protein and sugar. The three phytosterols were identified as beta-sitosterol (PS1), 31-norcyclolaudenone (PS2) and (24R)-4 alpha, 14 alpha, 4-trimethyl-5 alpha-cholesta-8, 25(27)-dien-3 beta-ol (PS3). IC50 values (the concentration of inhibiting 50% of enzyme activity) of PS1, PS2 and PS3 against alpha-glucosidase were 283.67, 11.33 and 43.10 mu g mL(-1), respectively. For inhibition of alpha-amylase, the IC50 values of PS1, PS2 and PS3 were 52.55, 76.25 and 532.02 mu g mL(-1), respectively. PS1 was an uncompetitive inhibitor against beta-amylase with K-m at 5.51 mu g mL(-1), while PS2 and PS3 exhibited a mixed-type inhibition with K-m at 52.36 and 2.49 mu g mL(-1), respectively. PS1 and PS2 also significantly inhibited the formation of advanced glycation end products (AGEs) in a BSA-fructose model. The results suggest that banana flower could possess the capability in prevention of the diseases associated with abnormal blood sugar and AGEs levels, such as diabetes.
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