Journal
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
Volume 43, Issue 1, Pages 78-82Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/bkcs.12433
Keywords
amyloid plaque; disaggregation; HEPES; neurodegenerative disease; sustained-release
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Funding
- Kyung Hee University [KHU-20201211]
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In this study, we found that HEPES is capable of disaggregating amyloid plaques associated with Alzheimer's disease. Additionally, we demonstrated its sustained-release system for up to 2 weeks through hybridization with a biocompatible polymer, Eudragit S100.
Here, we report the results of experiments regarding the chemical repositioning of 4-(2-hydroxyethyl)-1-piperazine ethane sulfonic acid (HEPES), a representative buffering agent. In this work, we confirmed that HEPES could disaggregate amyloid plaques, a hallmark of Alzheimer's disease, and we verified its sustained-release system (release for up to 2 weeks) via hybridization with a biocompatible polymer (Eudragit S100).
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