The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma

Article Oncology

LncRNA BRCAT54 inhibits the tumorigenesis of non-small cell lung cancer by binding to RPS9 to transcriptionally regulate JAK-STAT and calcium pathway genes

Wenhan Yang et al.

Summary: This study identified BRCAT54 as a tumor suppressor in NSCLC, and targeting the BRCAT54 and RPS9 feedback loop might be a novel therapeutic strategy for NSCLC.

CARCINOGENESIS (2021)

Add to Collection

Article Oncology

LncRNA MCF2L-AS1 aggravates proliferation, invasion and glycolysis of colorectal cancer cells via the crosstalk with miR-874-3p/FOXM1 signaling axis

Zhandong Zhang et al.

Summary: The study revealed that MCF2L-AS1 plays a crucial role in CRC by modulating the miR-874-3p/FOXM1 axis to promote tumorigenesis and glycolysis progression.

CARCINOGENESIS (2021)

Add to Collection

Article Cell Biology

miR-139-5p sponged by LncRNA NEAT1 regulates liver fibrosis via targeting β-catenin/SOX9/TGF-β1 pathway

Qi Wang et al.

Summary: The study highlighted the regulatory role of lncRNA NEAT1 and miR-139-5p in liver fibrosis progression, with NEAT1 promoting HSCs activation by sponging miR-139-5p. The overexpression of miR-139-5p or knockdown of NEAT1 alleviated liver fibrosis in vivo by targeting the beta-catenin/SOX9/TGF-beta 1 pathway.

CELL DEATH DISCOVERY (2021)

Add to Collection

Article Cell Biology

Exosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4

Yu-Shui Ma et al.

Summary: Exosomal miR-15a derived from MSCs can inhibit the proliferative, migrating, and invasive abilities of HCC cells by downregulating SALL4 expression. The exosomes successfully deliver miR-15a to HCC cells, leading to decreased tumorigenicity and metastasis of HCC tumors. In vivo experiments in nude mice further confirmed the inhibitory effects of exosomal miR-15a on HCC development.

CELL DEATH DISCOVERY (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

TV-circRGPD6 Nanoparticle Suppresses Breast Cancer Stem Cell-Mediated Metastasis via the miR-26b/YAF2 Axis

Xiaoti Lin et al.

Summary: By targeting the regulation of circRGPD6 on metastatic breast cancer stem cells, a new therapeutic approach has been developed to inhibit the expression of stem cell markers and increase the expression of DNA damage markers. TV-circRGPD6 significantly suppresses the metastasis of breast cancer stem cells and works synergistically with docetaxel to provide significant therapeutic responses for metastatic breast cancer.

MOLECULAR THERAPY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

The Epigenetic landscape of Circulating tumour cells

Sai Shyam Vasantharajan et al.

Summary: Cancer metastasis is a major cause of high mortality rates, with CTCs potentially serving as minimally invasive biomarkers for early detection and therapeutic monitoring. However, research on CTCs is limited due to their low numbers and the lack of robust isolation methods. Molecular characterization of CTCs is needed to identify tumor-specific features for clinical implications.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

Add to Collection

Article Oncology

Upregulation lnc-NEAT1 contributes to colorectal cancer progression through sponging miR-486-5p and activating NR4A1/Wnt/beta-catenin pathway

Zhining Liu et al.

Summary: NEAT1 and NR4A1 are highly expressed in colorectal cancer, knockdown of NEAT1 or NR4A1 can inhibit proliferation and motility of cancer cells, and induce apoptosis. NEAT1 contributes to colorectal cancer progression through mediating NR4A1/Wnt/beta-catenin signaling pathway.

CANCER BIOMARKERS (2021)

Add to Collection

Article Cell Biology

Inflammatory microenvironment of fibrotic liver promotes hepatocellular carcinoma growth, metastasis and sorafenib resistance through STAT3 activation

Yuchuan Jiang et al.

Summary: This study found that persistent liver injury promotes the growth and metastasis of HCC, which is positively correlated with the degree of liver inflammation rather than the extent of liver fibrosis. Inflammatory cytokines in liver tissue were clearly increased after liver injury. The two indicated cytokines, TNF-α and IL-6, both promoted intrahepatic HCC progression via STAT3 activation.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Inhibition of lncRNA MAAT Controls Multiple Types of Muscle Atrophy by cis- and trans-Regulatory Actions

Jin Li et al.

Summary: lncMAAT is identified as a common regulator of skeletal muscle atrophy, which is downregulated in multiple models and can ameliorate muscle atrophy by negatively regulating miR29b and positively regulating Mbnl1 expression. Overexpression of lncMAAT may represent a promising therapy for muscle atrophy induced by different stimuli.

MOLECULAR THERAPY (2021)

Add to Collection

Article Oncology

Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas

Haosheng Ni et al.

Summary: The mRNA levels of STAT1/2/4/5A/6 were significantly upregulated in HNSC tissues, and patients with high STAT5A levels had poor survival rates. Genetic alterations and immune cell infiltration analysis revealed a correlation between the STAT family and HNSC.

TRANSLATIONAL ONCOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARa axis

Zhi Zhang et al.

Summary: This study reveals that high-fat diet leads to the development of fatty liver in obese mice, with TRAF6 mediating ubiquitination of EZH2 to increase miR-429 expression that targets PPARa. TRAF6 promotes cholesterol accumulation in liver cells through the EZH2/miR-429/PPARa axis.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Add to Collection

Article Oncology

A survivin-driven, tumor-activatable minicircle system for prostate cancer theranostics

TianDuo Wang et al.

Summary: The study developed a novel cancer detection and treatment method based on a minicircle system, which has potential clinical applications. By regulating tumor-specific promoters, the system can specifically express transgenes in cancer cells and achieve urine-based cancer detection and gene-directed enzyme prodrug therapy.

MOLECULAR THERAPY-ONCOLYTICS (2021)

Add to Collection

Article Oncology

Oncogenic transcriptomic profile is sustained in the liver after the eradication of the hepatitis C virus

Haruhiko Takeda et al.

Summary: This study revealed that some oncogenic transcriptomic profiles persist in liver tissues after hepatitis C virus eradication, which may serve as a molecular basis for liver cancer development even after viral clearance. Among them, up-regulated CYR61 could potentially be a biomarker for hepatocellular carcinoma after sustained virologic response.

CARCINOGENESIS (2021)

Add to Collection

Article Cell Biology

KDM5A silencing transcriptionally suppresses the FXYD3-PI3K/AKT axis to inhibit angiogenesis in hepatocellular cancer via miR-433 up-regulation

Yu-Shui Ma et al.

Summary: This study investigates the role of KDM5A in angiogenesis and mechanisms in HCC, revealing that KDM5A suppresses miR-433 and activates the FXYD3-PI3K-AKT axis to promote HCC progression.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

USP22 deficiency in melanoma mediates resistance to T cells through IFNγ-JAK1-STAT1 signal axis

Min Li et al.

Summary: The study utilized CRISPR-Cas9 technology to screen melanoma cells, revealing that deletion or overexpression of specific genes can affect cell sensitivity to T cell-mediated killing. USP22 may regulate tumor cell escape ability through the interferon pathway. This research uncovers a novel immune evasion mechanism.

MOLECULAR THERAPY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Androgen receptor promotes renal cell carcinoma (RCC) vasculogenic mimicry (VM) via altering TWIST1 nonsense-mediated decay through lncRNA-TANAR

Bosen You et al.

Summary: The study suggests that androgen receptor (AR) promotes vasculogenic mimicry (VM) formation in ccRCC cells by regulating lncRNA-TANAR/TWIST1 signals, potentially impacting metastasis. This discovery provides a clue for the development of a novel anti-angiogenesis therapy to better suppress ccRCC progression.

ONCOGENE (2021)

Add to Collection

Review Pharmacology & Pharmacy

Dysregulation of lncRNAs in Rheumatoid Arthritis: Biomarkers, Pathogenesis and Potential Therapeutic Targets

Chenggui Miao et al.

Summary: Long noncoding RNAs (lncRNAs) play a key role in the pathogenesis of rheumatoid arthritis (RA), with their abnormal expression closely associated with disease development. Studies have also shown that lncRNAs have important roles in the diagnosis, regulation, and treatment of RA.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection

Article Oncology

SNHG1 knockdown upregulates miR-376a and downregulates FOXK1/Snail axis to prevent tumor growth and metastasis in HCC

Fanzhi Meng et al.

Summary: Long non-coding RNAs (lncRNAs), microRNAs (miRNAs or miRs), and genes play important roles in cancer progression. Through experiments on HCC cells and nude mouse models, it was found that knockdown of SNHG1 had anti-tumor activity in HCC by regulating the SNHG1/miR-376/FOXK1/Snail axis and delaying cancer progression. Targeting SNHG1 may be a potential therapeutic strategy for HCC.

MOLECULAR THERAPY-ONCOLYTICS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells

Nadia Flores-Huerta et al.

Summary: Breast cancer stem cells (bCSC), as a small subset of tumor cells with self-renewal properties and tumorigenic characteristics, play a key role in the development of breast cancer. Studies have shown that non-coding RNAs such as lncRNAs and miRNAs play important roles in regulating the stemness of bCSC.

BIOMOLECULES (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Cyclodextrins, Natural Compounds, and Plant Bioactives-A Nutritional Perspective

Svenja Wuepper et al.

Summary: Cyclodextrins are cyclic oligosaccharides with unique structures that enhance the water solubility and bioavailability of lipophilic substances. Complexation with cyclodextrins can improve the stability and bioactivity of natural compounds, while gamma CD itself exhibits metabolic activity, presenting new opportunities for applications.

BIOMOLECULES (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Actin Cytoskeleton and Regulation of TGF beta Signaling: Exploring Their Links

Roberta Melchionna et al.

Summary: Human tissues respond to injuries through activating biochemical and physical mechanisms that regulate intercellular communication crucial for maintaining tissue homeostasis. The communication coordination occurs through actin cytoskeletal regulators physically connected to the extracellular matrix, generating a signaling platform deregulated in cancer. The cytokine TGF-β remains a complex and central signaling network in cancer progression, with its link to actin dynamics being explored for their aberrant interaction.

BIOMOLECULES (2021)

Add to Collection

Article Oncology

3D human liver organoids: An in vitro platform to investigate HBV infection, replication and liver tumorigenesis

Shringar Rao et al.

Summary: Hepatitis B Virus (HBV) infection is a major cause of chronic liver cirrhosis and hepatocellular carcinoma (HCC) worldwide, and organoid technology has emerged as a powerful tool for studying this disease.

CANCER LETTERS (2021)

Add to Collection

Article Medicine, Research & Experimental

SUMOylation promotes extracellular vesicle-mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer

Changhao Chen et al.

Summary: This study reveals that SUMOylation is a crucial mechanism promoting lymphatic metastasis in bladder cancer, by regulating the ELNAT1/UBC9/SOX18 axis to enhance lymphangiogenesis and LN metastasis. Blocking tumor cell SUMOylation could be a promising therapeutic strategy for LN metastatic BCa.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Article Medicine, Research & Experimental

PRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemia

Duanfeng Jiang et al.

Summary: The study found that PRICKLE1 expression levels were significantly higher in AML patients at diagnosis, decreased after complete remission, and increased again at relapse. High PRICKLE1 expression was associated with drug resistant AML cells and monocytic-AML patients, as well as with poor prognosis in FLT3/DNMT3A/IDH1/IDH2-mutant AML.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

Add to Collection

Review Biochemistry & Molecular Biology

lncRNA PVT1 in the Pathogenesis and Clinical Management of Renal Cell Carcinoma

Julia Bohosova et al.

Summary: PVT1 plays a crucial role in RCC development and there is a significant amount of research trying to uncover its cellular mechanisms. This review summarizes the current knowledge on the role of PVT1 in RCC development and its association with clinical behavior. 17 scientific papers analyzed in this review provide robust support for the importance of PVT1 in RCC development and personalized therapy.

BIOMOLECULES (2021)

Add to Collection

Article Immunology

Lentivirus-Mediated Overexpression or Silencing of Aquaporin I Affects the Proliferation, Migration and Invasion of TNF-alpha-Stimulated Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Wnt/beta-Catenin Signaling Pathway

Meng-yuan Zhou et al.

Summary: The study revealed that AQP1 affects proliferation, migration, and invasion of TNF-alpha-stimulated MH7A cells through the Wnt/beta-catenin signaling pathway, suggesting AQP1 as a crucial regulator in the biologic behaviors of RA FLS.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Paradoxical functions of long noncoding RNAs in modulating STAT3 signaling pathway in hepatocellular carcinoma

Chakrabhavi Dhananjaya Mohan et al.

Summary: Hepatocellular carcinoma (HCC) is a deadly cancer with a high mortality rate, and STAT3 plays a crucial role in its development by regulating various genes and cellular functions. Long noncoding RNAs (lncRNAs) influence STAT3 signaling through diverse molecular mechanisms, impacting the pathogenesis and progression of HCC.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Role of microRNAs in regulating cell proliferation, metastasis and chemoresistance and their applications as cancer biomarkers in small cell lung cancer

Monu Pandey et al.

Summary: SCLC, a smoking-related aggressive cancer, shows universal loss of TP53 and RB1 tumor suppressor genes, with miRNAs playing a key role in regulating cell processes and potential clinical applications in monitoring chemotherapy responses and predicting survival outcomes.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

Add to Collection

Article Cell Biology

Circular RNA circE2F2 promotes malignant progression of ovarian cancer cells by upregulating the expression of E2F2 protein via binding to HuR protein

Meiyin Zhang et al.

Summary: The study found that circE2F2 promotes OC cell proliferation, metastasis, and glucose metabolism by stabilizing E2F2 mRNA via binding to the HuR protein. These findings reveal a novel regulatory mechanism for the oncogenic effects of circE2F2, E2F2, and HuR on ovarian carcinogenesis.

CELLULAR SIGNALLING (2021)

Add to Collection

Review Cell Biology

The role of the extracellular matrix protein TGFBI in cancer

Armando Corona et al.

Summary: TGFBI plays a dual role in cancer progression, acting as a tumor suppressor in the context of hereditary corneal dystrophies and promoting tumor progression in established tumors. Targeting TGFBI may have potential clinical utility in treating advanced cancers and assessing TGFBI levels could serve as a biomarker for chemotherapy resistance and tumor progression.

CELLULAR SIGNALLING (2021)

Add to Collection

Article Cell Biology

Transcriptome wide analysis of long non-coding RNA-associated ceRNA regulatory circuits in psoriasis

Jingxia Lin et al.

Summary: Long non-coding RNAs (lncRNAs) are involved in the pathogenesis of psoriasis and extensively interact with IFN-gamma signalling pathway associated genes. Experimental validation demonstrated certain lncRNAs' functional roles in the activation of inflammatory cytokine genes upon IFN-gamma stimulation. Furthermore, lncRNAs may regulate JAK/STAT pathway activity through a ceRNA mechanism.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Add to Collection

Article Oncology

A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity

Jun Sun et al.

Summary: The novel lncRNA ARST is significantly downregulated in gliomas, and overexpression of ARST suppresses vital cellular abilities in glioma cells, including cell growth, proliferation, migration, and invasion, ultimately reducing tumorigenicity in vivo. The tumor suppressive effects of ARST are mediated by direct binding to the glycolytic enzyme ALDOA, disrupting the interaction with actin cytoskeleton and altering the invasive properties of glioma cells. This highlights ARST as a potential target for glioma diagnosis, therapy, and prognosis.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Add to Collection

Article Oncology

Non-coding RNAs in cancer-associated cachexia: clinical implications and future perspectives

Anastasi Kottorou et al.

Summary: The passage discusses the characteristics and pathogenesis of cachexia, emphasizing the role of inflammatory reactions and the potential therapeutic value of ncRNAs in regulating pathways involved in cancer cachexia. Additionally, it highlights the involvement of circulating and exosomal ncRNAs in the activation and maintenance of systemic inflammation in cancer and cancer-associated cachexia.

TRANSLATIONAL ONCOLOGY (2021)

Add to Collection

Article Oncology

Amplification of RAD54B promotes progression of hepatocellular carcinoma via activating the Wnt/β-catenin signaling

Senwen Feng et al.

Summary: RAD54B is significantly upregulated in HCC and may serve as a potential prognostic marker and therapeutic target; RAD54B promotes HCC progression mainly through modulating the Wnt/β-catenin signaling pathway; Inhibition of the Wnt/β-catenin signaling pathway can counteract the activating effects of RAD54B on the motility of HCC cells.

TRANSLATIONAL ONCOLOGY (2021)

Add to Collection

Article Oncology

IRF2 regulates cellular survival and Lenvatinib-sensitivity of hepatocellular carcinoma (HCC) through regulating β-catenin

Yarong Guo et al.

Summary: IRF2 promotes proliferation, inhibits apoptosis, and increases lenvatinib resistance of HCC cells by regulating fl-catenin expression. The expression of fl-catenin and IRF2 is positively correlated in HCC tissues. Inhibiting fl-catenin effectively abrogates lenvatinib resistance caused by lenvatinib treatment. Targeting IRF2 may improve the therapeutic effect of lenvatinib on HCC.

TRANSLATIONAL ONCOLOGY (2021)

Add to Collection

Review Pharmacology & Pharmacy

The Research Progress of Exosomes in Osteoarthritis, With Particular Emphasis on the Mediating Roles of miRNAs and lncRNAs

Chenggui Miao et al.

Summary: Exosomes play important roles in the pathogenesis of osteoarthritis by regulating cell communication and biological activity through carrying RNA and proteins. Therefore, exploring the roles of exosomes in osteoarthritis can help to better understand the disease mechanism and discover new diagnostic biomarkers and therapeutic targets.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

lncRNA MIR210HG promotes the progression of endometrial cancer by sponging miR-337-3p/137 via the HMGA2-TGF-f3/Wnt pathway

Jian Ma et al.

Summary: EMT promotes tumorigenesis and metastasis while increasing tumor tolerance to treatment. MIR210HG overexpression in endometrial cancer tissues is associated with poor prognosis, and its regulation of the miR-337-3p/137-HMGA2 axis suggests potential as a therapeutic target for endometrial cancer.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Add to Collection

Article Oncology

Secretion of bispecific protein of anti-PD-1 fused with TGF-β trap enhances antitumor efficacy of CAR-T cell therapy

Xianhui Chen et al.

Summary: Despite the limitations posed by the immunosuppressive tumor microenvironment and immune checkpoints, engineered CAR-T cells that secrete bispecific trap protein targeting PD-1 and TGF-beta have shown promising potential in enhancing antitumor immunity for solid tumors, as demonstrated in in vitro and in vivo experiments.

MOLECULAR THERAPY-ONCOLYTICS (2021)

Add to Collection

Article Oncology

IncRNA MIR503HG inhibits cell proliferation and promotes apoptosis in TNBC cells via the miR-224-5p/HOXA9 axis

Shou-Man Wang et al.

Summary: The study revealed that MIR503HG inhibits the proliferation of triple-negative breast cancer cells via the miR-224-5p/HOXA9 axis, promoting apoptosis and exhibiting a suppressive effect on tumor growth.

MOLECULAR THERAPY-ONCOLYTICS (2021)

Add to Collection

Article Oncology

Upregulation of Long Noncoding RNA_GAS5 Suppresses Cell Proliferation and Metastasis in Laryngeal Cancer via Regulating PI3K/AKT/mTOR Signaling Pathway

Wenlin Liu et al.

Summary: The study showed that lncRNA GAS5 is downregulated in laryngeal cancer, and its low expression is correlated with poor tumor differentiation, advanced stage, lymph node metastasis, and shorter survival time. Upregulation of lncRNA GAS5 significantly inhibits cell proliferation and metastasis by regulating the PI3K/AKT/mTOR signaling pathway.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2021)

Add to Collection

Letter Biochemistry & Molecular Biology

P21-activated kinase 5 potentiates the chemoresistant phenotype of liver cancer

Ding-Guo Zhang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Add to Collection

Article Immunology

Downregulation of Renal MRPs Transporters in Acute Lymphoblastic Leukemia Mediated by the IL-6/STAT3/PXR Signaling Pathway

Yue Zhou et al.

Summary: Elevated plasma IL-6 levels were observed in patients with newly diagnosed acute lymphoblastic leukemia (ALL), and IL-6/STAT3/PXR signaling pathway was found to affect the expression of MRP2 and MRP4, potentially mediating the clearance of MTX in ALL patients. Blocking the IL-6/STAT3/PXR signaling pathway may attenuate these effects.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Add to Collection

Article Medicine, Research & Experimental

LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex suppresses UBXN1 expression and activates NF-KB activity, promoting tumorigenesis

Yansheng Li et al.

Summary: The study identified a novel cancer driver lncRNA named PRADX in glioblastoma and colon adenocarcinoma, which is highly expressed in tumor cells and tissues. Through various experiments, PRADX was found to interact with EZH2 protein, increase H3K27 trimethylation in the UBXN1 gene promoter, and promote NF-KB activity by suppressing UBXN1. Knockdown of PRADX inhibited tumor cell viability and growth both in vitro and in vivo, suggesting its potential as a therapeutic target for these cancers.

THERANOSTICS (2021)

Add to Collection

Article Cell Biology

The lncRNA SNHG16 affects prognosis in hepatocellular carcinoma by regulating p62 expression

Jian-Hong Zhong et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

Add to Collection

Article Cell Biology

LncRNA NEAT1 promotes autophagy via regulating miR-204/ATG3 and enhanced cell resistance to sorafenib in hepatocellular carcinoma

Xinyu Li et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

Add to Collection

Article Oncology

Long noncoding RNA CASC2c inhibited cell proliferation in hepatocellular carcinoma by inactivated ERK1/2 and Wnt/β-catenin signaling pathway

Q. Y. Li et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2020)

Add to Collection

Article Oncology

A positive feedback loop involving the LINC00346/β-catenin/MYC axis promotes hepatocellular carcinoma development

Nuobei Zhang et al.

CELLULAR ONCOLOGY (2020)

Add to Collection

Article Medicine, Research & Experimental

Long Noncoding RNA UCA1 Regulates PRL-3 Expression by Sponging MicroRNA-495 to Promote the Progression of Gastric Cancer

Yi Cao et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Challenges in liver cancer and possible treatment approaches

David Anwanwan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Add to Collection

Article Oncology

Long non-coding RNA TUG1 promotes cell progression in hepatocellular carcinoma via regulating miR-216b-5p/DLX2 axis

Qun Dai et al.

CANCER CELL INTERNATIONAL (2020)

Add to Collection

Article Oncology

LncRNA BCYRN1/miR-490-3p/POU3F2, served as a ceRNA network, is connected with worse survival rate of hepatocellular carcinoma patients and promotes tumor cell growth and metastasis

Shichao Ding et al.

CANCER CELL INTERNATIONAL (2020)

Add to Collection

Article Oncology

Acetylation of alpha-fetoprotein promotes hepatocellular carcinoma progression

Junhui Xue et al.

CANCER LETTERS (2020)

Add to Collection

Article Cell Biology

Long non-coding RNA SUMO1P3 promotes hepatocellular carcinoma progression through activating Wnt/β-catenin signalling pathway by targeting miR-320a

Songsong Wu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Add to Collection

Article Cell Biology

Long noncoding RNA TCL6 binds to miR-106a-5p to regulate hepatocellular carcinoma cells through PI3K/AKT signaling pathway

Li-Hua Luo et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

Add to Collection

Article Oncology

Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating Wnt/β-catenin signaling

Xiaohui Tian et al.

MOLECULAR ONCOLOGY (2020)

Add to Collection

Article Cell Biology

Long non-coding RNA DLGAP1-AS1 facilitates tumorigenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via the feedback loop of miR-26a/b-5p/IL-6/JAK2/STAT3 and Wnt/β-catenin pathway

Ye Lin et al.

CELL DEATH & DISEASE (2020)

Add to Collection

Article Cell Biology

LncRNA RUNX1-IT1 which is downregulated by hypoxia-driven histone deacetylase 3 represses proliferation and cancer stem-like properties in hepatocellular carcinoma cells

Liankang Sun et al.

CELL DEATH & DISEASE (2020)

Add to Collection

Article Cell Biology

Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs

Chia-Pei Yang et al.

AGING CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

被撤回的出版物: HBx/ER alpha complex-mediated LINC01352 downregulation promotes HBV-related hepatocellular carcinoma via the miR-135b-APC axis (Retracted article. See JUN, 2023)

Pinbo Huang et al.

ONCOGENE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

The β-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 axis promotes hepatocellular carcinoma metastasis

Wei-Juan Huang et al.

ONCOGENE (2020)

Add to Collection

Article Medical Laboratory Technology

Serum expression and diagnostic potential of long non-coding RNAs NEAT1 and TUG1 in viral hepatitis C and viral hepatitis C-associated hepatocellular carcinoma

Mai Mohyeldeen et al.

CLINICAL BIOCHEMISTRY (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

A Circulating Long Noncoding RNA Panel Serves as a Diagnostic Marker for Hepatocellular Carcinoma

Jinlan Huang et al.

DISEASE MARKERS (2020)

Add to Collection

Review Biochemistry & Molecular Biology

New insights on sorafenib resistance in liver cancer with correlation of individualized therapy

Zhang Cheng et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Add to Collection

Article Biochemistry & Molecular Biology

LncRNA HOTAIR contributes Taxol-resistance of hepatocellular carcinoma cells via activating AKT phosphorylation by down-regulating miR-34a

Yunfei Duan et al.

BIOSCIENCE REPORTS (2020)

Add to Collection

Article Oncology

Oncolytic virotherapy armed with an engineered interfering lncRNA exhibits antitumor activity by blocking the epithelial mesenchymal transition in triple-negative breast cancer

Lin Ang et al.

CANCER LETTERS (2020)

Add to Collection

Article Oncology

Oncogenic HBV variants and integration are present in hepatic and lymphoid cells derived from chronic HBV patients

Keith C. K. Lau et al.

CANCER LETTERS (2020)

Add to Collection

Article Oncology

miR-155 Accelerates the Growth of Human Liver Cancer Cells by Activating CDK2 via Targeting H3F3A

Xiaoru Xin et al.

MOLECULAR THERAPY-ONCOLYTICS (2020)

Add to Collection

Article Oncology

Hypoxia-Induced lncRNA-NEAT1 Sustains the Growth of Hepatocellular Carcinoma via Regulation of miR-199a-3p/UCK2

Qiangnu Zhang et al.

FRONTIERS IN ONCOLOGY (2020)

Add to Collection

Article Cell Biology

An allele of rs619586 polymorphism in MALAT1 alters the invasiveness of meningioma via modulating the expression of collagen type V alpha (COL5A1)

Jie Zheng et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Add to Collection

Article Cell Biology

Corilagin suppresses RANKL-induced osteoclastogenesis and inhibits oestrogen deficiency-induced bone loss via the NF-κB and PI3K/AKT signalling pathways

Jinwei Lu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Add to Collection

Article Cell Biology

Curcumin reinforces MSC-derived exosomes in attenuating osteoarthritis via modulating the miR-124/NF-kB and miR-143/ROCK1/TLR9 signalling pathways

Bo Qiu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Decrease in Chitinase 3-Like Protein 1 Levels Reflects Improvement in Liver Fibrosis after HCV Eradication

Qian Kang et al.

DISEASE MARKERS (2020)

Add to Collection

Article Oncology

The long noncoding RNA OTUD6B-AS1 enhances cell proliferation and the invasion of hepatocellular carcinoma cells through modulating GSKIP/Wnt/beta-catenin signalling via the sequestration of miR-664b-3p

Shuzhen Kong et al.

EXPERIMENTAL CELL RESEARCH (2020)

Add to Collection

Article Cell Biology

A disintegrin and metalloproteinase 8 induced epithelial-mesenchymal transition to promote the invasion of colon cancer cells via TGF-β/Smad2/3 signalling pathway

Qianna Jin et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Add to Collection

Article Multidisciplinary Sciences

Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation

Marco Napoli et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Medicine, Research & Experimental

被撤回的出版物: Long Noncoding RNA OIP5-AS1 Promotes the Progression of Liver Hepatocellular Carcinoma via Regulating the hsa-miR-26a-3p/EPHA2 Axis (Retracted article. See vol. 30, pg. 324, 2022)

Yu-Shui Ma et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Add to Collection

Article Oncology

Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells

Jia-Bao Yan et al.

MOLECULAR THERAPY-ONCOLYTICS (2020)

Add to Collection

Article Oncology

Suppression of lncRNA MALAT1 by betulinic acid inhibits hepatocellular carcinoma progression by targeting IAPs via miR-22-3p

Feiyu Chen et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2020)

Add to Collection

Article Oncology

The interplay between ATF2 and NEAT1 contributes to lung adenocarcinoma progression

Jian Liu et al.

CANCER CELL INTERNATIONAL (2020)

Add to Collection

Review Cell Biology

Fibroblast mechanosensing, SKI and Hippo signaling and the cardiac fibroblast phenotype: Looking beyond TGF-β

Natalie M. Landry et al.

CELLULAR SIGNALLING (2020)

Add to Collection

Article Cell Biology

LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis

Bin Yang et al.

CELLULAR SIGNALLING (2020)

Add to Collection

Article Medicine, Research & Experimental

miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling

Peng Xu et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Add to Collection

Article Oncology

Valeric Acid Suppresses Liver Cancer Development by Acting as a Novel HDAC Inhibitor

Rui Han et al.

MOLECULAR THERAPY-ONCOLYTICS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Transcriptional Profiling Reveals Ribosome Biogenesis, Microtubule Dynamics and Expression of Specific lncRNAs to be Part of a Common Response to Cell-Penetrating Peptides

Tomas Venit et al.

BIOMOLECULES (2020)

Add to Collection

Article Biochemistry & Molecular Biology

The PVT1 lncRNA is a novel epigenetic enhancer of MYC, and a promising risk-stratification biomarker in colorectal cancer

Kunitoshi Shigeyasu et al.

MOLECULAR CANCER (2020)

Add to Collection

Article Oncology

LINC00355:8 promotes cell proliferation and migration with invasion via the MiR-6777-3p/Wnt10b axis in Hepatocellular Carcinoma

Fangyuan Zhou et al.

JOURNAL OF CANCER (2020)

Add to Collection

Article Oncology

LncRNA MIR22HG inhibits growth, migration and invasion through regulating the miR-10a-5p/NCOR2 axis in hepatocellular carcinoma cells

Yangjun Wu et al.

CANCER SCIENCE (2019)

Add to Collection

Article Biochemistry & Molecular Biology

The long noncoding RNA cardiac hypertrophy-related factor plays oncogenic roles in hepatocellular carcinoma by downregulating microRNA-211

Yichun Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Add to Collection

Article Gastroenterology & Hepatology

C1QTNF1-AS1 regulates the occurrence and development of hepatocellular carcinoma by regulating miR-221-3p/SOCS3

Hang Li et al.

HEPATOLOGY INTERNATIONAL (2019)

Add to Collection

Article Oncology

The long noncoding RNA AK002107 negatively modulates miR-140-5p and targets TGFBR1 to induce epithelial-mesenchymal transition in hepatocellular carcinoma

Yun-Hua Tang et al.

MOLECULAR ONCOLOGY (2019)

Add to Collection

Article Oncology

Long non-coding RNA PTTG3P functions as an oncogene by sponging miR-383 and up-regulating CCND1 and PARP2 in hepatocellular carcinoma

Qiang Zhou et al.

BMC CANCER (2019)

Add to Collection

Article Cell Biology

MALAT1 accelerates the development and progression of renal cell carcinoma by decreasing the expression of miR-203 and promoting the expression of BIRC5

Haimin Zhang et al.

CELL PROLIFERATION (2019)

Add to Collection

Article Cell Biology

LncRNA MEG3 inhibits cell proliferation and induces apoptosis in laryngeal cancer via miR-23a/APAF-1 axis

Xiaowen Zhang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Add to Collection

Article Genetics & Heredity

Role of BCYRN1 in hepatocellular carcinoma pathogenesis by lncRNA-miRNA-mRNA network analysis and its diagnostic and prognostic value

Xin-Liang Ming et al.

EPIGENOMICS (2019)

Add to Collection

Article Immunology

Long noncoding RNA HAGLROS promotes cell proliferation, inhibits apoptosis and enhances autophagy via regulating miR-5095/ATG12 axis in hepatocellular carcinoma cells

Huamei Wei et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Add to Collection

Article Oncology

LncRNA ANRIL promotes cell growth, migration and invasion of hepatocellular carcinoma cells via sponging miR-144

Yongbiao Ma et al.

ANTI-CANCER DRUGS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Overexpression of CASC2 Improves Cisplatin Sensitivity in Hepatocellular Carcinoma Through Sponging miR-222

Zhichun Liu et al.

DNA AND CELL BIOLOGY (2019)

Add to Collection

Article Oncology

被撤回的出版物: LncRNA ASB16-AS1 Promotes Growth And Invasion Of Hepatocellular Carcinoma Through Regulating miR-1827/FZD4 Axis And Activating Wnt/beta-Catenin Pathway (Retracted article. See vol. 14, pg. 501, 2022)

Xiaoxiao Yao et al.

CANCER MANAGEMENT AND RESEARCH (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Long non-coding RNA FENDRR inhibits proliferation and invasion of hepatocellular carcinoma by down-regulating glypican-3 expression

Bian Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Bioinformatic analysis of the prognostic value of the lncRNAs encoding snoRNAs in hepatocellular carcinoma

Qingyao Zhu et al.

BIOFACTORS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

lncRNA A1BG-AS1 suppresses proliferation and invasion of hepatocellular carcinoma cells by targeting miR-216a-5p

Jigang Bai et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Add to Collection

Article Cell Biology

The long noncoding RNA NORAD enhances the TGF- pathway to promote hepatocellular carcinoma progression by targeting miR-202-5p

Xuan Yang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Add to Collection

Article Biology

lncRNA MEG3 inhibits the growth of hepatocellular carcinoma cells by sponging miR-9-5p to upregulate SOX11

Zhi Liu et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2019)

Add to Collection

Article Cell Biology

LINC00152 promotes cell cycle progression in hepatocellular carcinoma via miR-193a/b-3p/CCND1 axis

Pei Ma et al.

CELL CYCLE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

LncRNA TUG1 interacting with miR-144 contributes to proliferation, migration and tumorigenesis through activating the JAK2/STAT3 pathway in hepatocellular carcinoma

Jun Lv et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

Add to Collection

Article Cell Biology

Long noncoding RNA CASC2 regulates hepatocellular carcinoma cell oncogenesis through miR-362-5p/Nf-B axis

Liang Zhao et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Add to Collection

Article Medicine, Research & Experimental

Identification and Functional Characterization of Long Non-coding RNA MIR22HG as a Tumor Suppressor for Hepatocellular Carcinoma

Dong-Yan Zhang et al.

THERANOSTICS (2018)

Add to Collection

Article Cell Biology

Long Non-Coding RNA PVT1/miR-150/HIG2 Axis Regulates the Proliferation, Invasion and the Balance of Iron Metabolism of Hepatocellular Carcinoma

Yunxiuxiu Xu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma

C. Cao et al.

ONCOGENE (2017)

Add to Collection

Article Oncology

Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes tumorigenesis and metastasis by targeting miR-199a/b-5p in hepatocellular carcinoma

Tian Lan et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Long non-coding RNA CASC2 suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells through CASC2/miR-367/FBXW7 axis

Yufeng Wang et al.

MOLECULAR CANCER (2017)

Add to Collection

Article Oncology

Long non-coding RNA PTENP1 interacts with miR-193a-3p to suppress cell migration and invasion through the PTEN pathway in hepatocellular carcinoma

Yu-Yuan Qian et al.

ONCOTARGET (2017)

Add to Collection

Article Biochemistry & Molecular Biology

被撤回的出版物: Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial-mesenchymal transition by regulating HIF-1α via miR-138 (Retracted article. See vol. 13, 2023)

Qiang Cai et al.

OPEN BIOLOGY (2017)

Add to Collection

Article Medicine, Research & Experimental

Linc00152 promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma

Xin Deng et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

The Aberrant Expression of MEG3 Regulated by UHRF1 Predicts the Prognosis of Hepatocellular Carcinoma

Han Zhuo et al.

MOLECULAR CARCINOGENESIS (2016)

Add to Collection

Review Cell Biology

TUG1: a pivotal oncogenic long non-coding RNA of human cancers

Zheng Li et al.

CELL PROLIFERATION (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Long noncoding RNA FTX inhibits hepatocellular carcinoma proliferation and metastasis by binding MCM2 and miR-374a

F. Liu et al.

ONCOGENE (2016)

Add to Collection

Article Oncology

LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway

Shi-Peng Li et al.

ONCOTARGET (2016)

Add to Collection

Article Oncology

MicroRNA-362-5p promotes tumor growth and metastasis by targeting CYLD in hepatocellular carcinoma

Fang Ni et al.

CANCER LETTERS (2015)

Add to Collection

Article Cell Biology

Long non-coding RNA Linc00152 is involved in cell cycle arrest, apoptosis, epithelial to mesenchymal transition, cell migration and invasion in gastric cancer

Jing Zhao et al.

CELL CYCLE (2015)

Add to Collection

Article Cell Biology

HULC and Linc00152 Act as Novel Biomarkers in Predicting Diagnosis of Hepatocellular Carcinoma

Jun Li et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)

Add to Collection

Article Genetics & Heredity

fMiRNA-192 and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma

Yunxia Ge et al.

PLOS GENETICS (2015)

Add to Collection

Article Gastroenterology & Hepatology

Oncofetal Long Noncoding RNA PVT1 Promotes Proliferation and Stem Cell-Like Property of Hepatocellular Carcinoma Cells by Stabilizing NOP2

Fang Wang et al.

HEPATOLOGY (2014)

Add to Collection

Article Cell Biology

A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma

J. Tang et al.

CELL DEATH & DISEASE (2014)

Add to Collection

Article Gastroenterology & Hepatology

The changing pattern of epidemiology in hepatocellular carcinoma

Helena Nordenstedt et al.

DIGESTIVE AND LIVER DISEASE (2010)

Add to Collection

The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma

Related references

Export Citation

Share Paper