Journal
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
Volume 13, Issue 11, Pages 1668-1679Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4251/wjgo.v13.i11.1668
Keywords
Pancreatic cancer; Ferroptosis; Reactive oxygen species; Iron metabolism; Lipid peroxides
Categories
Funding
- National Natural Science Foundation of China [81970569, 81773293]
- Natural Science Foundation of Hunan Province [2017SK50121]
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Ferroptosis is a novel form of cell death that plays a significant role in the occurrence and development of various tumors, including pancreatic cancer. Regulating ferroptosis-induced cell death in pancreatic cancer can inhibit tumor growth and enhance treatment sensitivity when combined with other antitumor drugs.
Pancreatic cancer is a highly lethal malignancy with low resection and survival rates and is not sensitive to radiotherapy and chemotherapy. Ferroptosis is a novel form of nonapoptotic regulated cell death characterized by the accumulation of lipid peroxides and reactive oxygen species involved in iron metabolism. Ferroptosis has a significant role in the occurrence and development of various tumors. Previous studies have shown that regulating ferroptosis-induced cell death inhibited tumor growth in pancreatic cancer and was synergistic with other antitumor drugs to improve treatment sensitivity. Herein, we discuss the mechanism, inducers, and developments of ferroptosis in pancreatic cancer to provide new strategies for the treatment of the malignancy.
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