Journal
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
Volume 13, Issue 12, Pages 2013-2028Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4251/wjgo.v13.i12.2013
Keywords
Colorectal cancer; Macrophages; Inflammatory transformation; Tumor microenvironment
Categories
Funding
- National Nature Science Foundation of China [81874206]
- Shanghai Rising-Star Program [20QA1409300]
- Program for Young Eastern Scholar at Shanghai Institutions of Higher Learning [QD2019034]
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Studies have shown that macrophages play a crucial role in the development of colorectal cancer, and the intestinal and hypoxic environments can also affect their function. Targeting macrophages may be a potential therapeutic strategy for CRC.
Colorectal cancer (CRC) is one of the most common and fatal cancers worldwide, and it is also a typical inflammatory cancer. The function of macrophages is very important in the tissue immune microenvironment during inflammatory and carcinogenic transformation. Here, we evaluated the function and mechanism of macrophages in intestinal physiology and in different pathological stages. Furthermore, the role of macrophages in the immune microenvironment of CRC and the influence of the intestinal population and hypoxic environment on macrophage function are summarized. In addition, in the era of tumor immunotherapy, CRC currently has a limited response rate to immune checkpoint inhibitors, and we summarize potential therapeutic strategies for targeting tumor-associated macrophages.
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