Journal
OPEN FORUM INFECTIOUS DISEASES
Volume 9, Issue 2, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofab648
Keywords
HIV; antiretroviral therapy; drug resistance; dolutegravir; integrase strand transfer inhibitor
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Multiclass high-level transmitted HIV drug resistance is uncommon, but this case highlights the successful treatment with dolutegravir, tenofovir, and emtricitabine even with extensive resistance. It emphasizes the high resistance barrier of dolutegravir and the residual antiviral activity of nucleoside reverse transcriptase inhibitors.
Multiclass high-level transmitted HIV drug resistance is uncommon, and the selection of the optimal initial antiretroviral drug regimen may be challenging. We report a case of extensive transmitted multiclass resistance successfully treated with dolutegravir, tenofovir, and emtricitabine even though the baseline genotype demonstrated full susceptibility to only 1 drug class, integrase strand transfer inhibitors. Our case highlights both the high resistance barrier of dolutegravir and the residual antiviral activity of nucleoside reverse transcriptase inhibitors despite extensive resistance on genotype.
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