Journal
PHARMACEUTICS
Volume 13, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics13111981
Keywords
rapid prototyping; GELPOR3D; silica-hydroxyapatite; mesoporous materials; meso-macroporous scaffolds; ceramic modifying agents
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Funding
- Instituto de Salud Carlos III [PI20/01384]
- European Union FEDER funds
- European Research Council [694160, ERC-2015-AdG]
- Spanish Ministerio de Ciencia e Innovacion [PID2019-106436RB-I00]
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This review explores the application of advanced bioceramics for bone regeneration, covering different types of materials, fabrication techniques, and the influence of biomolecules, drugs, or cells within scaffolds.
Advanced bioceramics for bone regeneration constitutes one of the pivotal interests in the multidisciplinary and far-sighted scientific trajectory of Prof. Vallet Regi. The different pathologies that affect osseous tissue substitution are considered to be one of the most important challenges from the health, social and economic point of view. 3D scaffolds based on bioceramics that mimic the composition, environment, microstructure and pore architecture of hard tissues is a consolidated response to such concerns. This review describes not only the different types of materials utilized: from apatite-type to silicon mesoporous materials, but also the fabrication techniques employed to design and adequate microstructure, a hierarchical porosity (from nano to macro scale), a cell-friendly surface; the inclusion of different type of biomolecules, drugs or cells within these scaffolds and the influence on their successful performance is thoughtfully reviewed.
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