Journal
PHARMACEUTICS
Volume 14, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics14010072
Keywords
photo-degradation; analytical methods; post-translational modification; protein degradation; reactive oxygen species
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This review addresses the analytical aspects of investigating photo-oxidation products and related mediators using established and novel techniques.
UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation processes and eventually protected from light exposure. This task usually demands the application and combination of various analytical methods. This review addresses analytical aspects of investigating photo-oxidation products and related mediators such as reactive oxygen species generated via UV and ambient light with well-established and novel techniques.
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