Exosomes as a New Delivery Vehicle in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a type of chronic relapsing inflammatory disease. The pathogenesis of IBD is still unclear, which may involve environmental factors, genetic factors, intestinal microbiota disorder, and abnormal immune responses. Exosomes (30-150 nm) are found in various body fluids, including blood, saliva, urine, and cerebrospinal fluid. Exosomes mediate intercellular communication and regulate cell biological activity by carrying non-coding RNAs, proteins, and lipids. There is evidence that exosomes are involved in the pathogenesis of IBD. In view of the important roles of exosomes in the pathogenesis of IBD, this work systematically reviews the latest research progress of exosomes in IBD, especially the roles of exosomes as non-coding RNA delivery systems in the pathogenesis of IBD, including a disordered immune response, barrier function, and intestinal microbiota. The review will help to clarify the pathogenesis of IBD and explore new diagnostic markers and therapeutic targets for patients with IBD.

Automated summary

Inflammatory bowel disease (IBD) is a type of chronic relapsing inflammatory disease with unclear pathogenesis involving environmental factors, genetic factors, intestinal microbiota disorder, and abnormal immune responses. Exosomes, with sizes ranging from 30-150 nm, are involved in IBD pathogenesis by mediating intercellular communication and regulating cell activity through non-coding RNAs, proteins, and lipids. Understanding the roles of exosomes in IBD may offer new diagnostic markers and therapeutic targets.