Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.785887
Keywords
BIA-ALCL; epidemiology; genetic predisposition; bacterial contamination; implant modification
Categories
Funding
- China Guanghua Science and Technology Foundation [2019JZXM001]
- Wuhan Science and Technology Bureau [2020020601012241]
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This article provides a review on the etiology, pathogenesis, diagnosis, and therapy of breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL). It also reviews the physical characteristics of breast implants and their potential pathogenic effect, aiming to provide a foundation for the optimal choice of implants with minimal morbidity.
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is an uncommon type of T-cell lymphoma. Although with a low incidence, the epidemiological data raised the biosafety and health concerns of breast reconstruction and breast augmentation for BIA-ALCL. Emerging evidence confirms that genetic features, bacterial contamination, chronic inflammation, and textured breast implant are the relevant factors leading to the development of BIA-ALCL. Almost all reported cases with a medical history involve breast implants with a textured surface, which reflects the role of implant surface characteristics in BIA-ALCL. With this review, we expect to highlight the most significant features on etiology, pathogenesis, diagnosis, and therapy of BIA-ALCL, as well as we review the physical characteristics of breast implants and their potential pathogenic effect and hopefully provide a foundation for optimal choice of type of implant with minimal morbidity.
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