Journal
FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.831997
Keywords
miRNA-30a-5p; NSCLC; prognosis biomarker; cell proliferation; cell migration
Categories
Funding
- National Nature Science Foundation of China [82160508]
- Yunnan Applied Basic Research Projects [YNWRMY-2019-067]
- Yunnan Province Specialized Training Grant for High-Level Healthcare Professionals [D-201614]
- Yunnan Province Applied Basic Research Foundation [2019FE001]
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The expression of miRNA-30a-5p is significantly decreased in LUAD and is associated with clinical outcomes and immune cell infiltration. Furthermore, miRNA-30a-5p has been found to inhibit cell proliferation and migration in LUAD.
MiRNA-30a-5p is a microRNA found to be decreased in various human cancers, including lung adenocarcinoma (LUAD). However, the molecular mechanisms of miRNA-30a-5p involve in the progression of LUAD remains unclear. In this study, we found that miRNA-30a-5p expression was significantly decreased in LUAD cells lines, LUAD tissues, and peripheral blood serum. Besides, LUAD patients with decreased miRNA-30a-5p expression exhibit worse clinical outcomes compared to the patients with higher miRNA-30a-5p expression, decreased expression of miRNA-30a-5p was associated with advanced clinical outcomes. Receiver operating characteristic (ROC) curve analysis of miRNA-30a-5p showed an area under the curve (AUC) value of 0.902, indicating its prognostic value in LUAD. Moreover, immune infiltration and gene set enrichment analysis (GSEA) enrichment analyze demonstrated that miRNA-30a-5p expression was associated with immune cell infiltrated in LUAD. Finally, we found that miRNA-30a-5p inhibits cell proliferation, migration, and self-renewal abilities of LUAD in vitro. In summary, this is the first report that miRNA-30a-5p correlated with progression and immune infiltration, which shed some lights on potential prognostic and therapeutic biomarker for LUAD.
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