Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.742149
Keywords
non-coding RNAs; ovarian cancer; chemotherapy; drug resistance (DR); cisplatin
Categories
Funding
- Key Project of Joint Funds of Hubei Health and Family Planning Commission [WJ2018H174]
- Postgraduate Innovation Fund Project of Yangtze University Health Science Center [202006]
- Natural Science Foundation of Hubei Province [2017CFB703]
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Non-coding RNAs play a crucial role in the development of chemotherapeutic resistance in ovarian cancer by promoting resistance through multiple pathways. Understanding the mechanisms and potential signaling pathways of these non-coding RNAs can facilitate the development of more effective treatment strategies.
Ovarian cancer, a common malignant tumor, is one of the primary causes of cancer-related deaths in women. Systemic chemotherapy with platinum-based compounds or taxanes is the first-line treatment for ovarian cancer. However, resistance to these chemotherapeutic drugs worsens the prognosis. The underlying mechanism of chemotherapeutic resistance in ovarian cancer remains unclear. Non-coding RNAs, including long non-coding RNAs, microRNAs, and circular RNAs, have been implicated in the development of drug resistance. Abnormally expressed non-coding RNAs can promote ovarian cancer resistance by inducing apoptosis inhibition, protective autophagy, abnormal tumor cell proliferation, epithelial-mesenchymal transition, abnormal glycolysis, drug efflux, and cancer cell stemness. This review summarizes the role of non-coding RNAs in the development of chemotherapeutic resistance in ovarian cancer, including their mechanisms, targets, and potential signaling pathways. This will facilitate the development of novel chemotherapeutic agents that can target these non-coding RNAs and improve ovarian cancer treatment.
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