Journal
FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.812480
Keywords
integrin; cancer; signaling transduction; talin; FAK
Categories
Funding
- National Natural Sciences Foundation of China [81872186]
- Natural Sciences Foundation of Fujian Province [2019J01318, 2018J01816]
- Fujian Provincial Education Department [JT180206]
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Integrins, a family of adhesion molecules on the cell surface, play a crucial role in regulating cell growth and function. Recent advances have revealed their significance in tumorigenesis and progression, making them a potential therapeutic target for cancer treatment.
Integrins, a family of adhesion molecules generally exist on the cell surface, are essential for regulating cell growth and its function. As a bi-directional signaling molecule, they mediate cell-cell and cell-extracellular matrix interaction. The recognitions of their key roles in many human pathologies, including autoimmunity, thrombosis and neoplasia, have revealed their great potential as a therapeutic target. This paper focuses on the activation of integrins, the role of integrins in tumorigenesis and progression, and advances of integrin-dependent tumor therapeutics in recent years. It is expected that understanding function and signaling transmission will fully exploit potentialities of integrin as a novel target for tumors.
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