Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.814699
Keywords
cardiotoxicity; cardio-oncology; pharmacokinetic and pharmacodynamic modeling; mechanistic modeling; toxicity; anti-cancer drugs
Categories
Funding
- Shanghai Rising Stars of Medical Talents Youth Development Program-Youth Medical Talents: Clinical Pharmacist Program [SHWSRS(2021)_099]
- Bethune Charitable Foundation [B-19-H-20200622]
- Wu Jieping Medical Foundation [320.6750.2020-10-103]
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The cardiotoxicity of anti-cancer drugs presents a challenge to clinicians and patients. However, mechanistic pharmacokinetic and pharmacodynamic modeling provides an important approach to predict and offer precise cardio-oncological care.
The cardiotoxicity of anti-cancer drugs presents as a challenge to both clinicians and patients. Significant advances in cancer treatments have improved patient survival rates, but have also led to the chronic effects of anti-cancer therapies becoming more prominent. Additionally, it is difficult to clinically predict the occurrence of cardiovascular toxicities given that they can be transient or irreversible, with large between-subject variabilities. Further, cardiotoxicities present a range of different symptoms and pathophysiological mechanisms. These notwithstanding, mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) modeling offers an important approach to predict cardiotoxicities and offering precise cardio-oncological care. Efforts have been made to integrate the structures of physiological and pharmacological networks into PK-PD modeling to the end of predicting cardiotoxicities based on clinical evaluation as well as individual variabilities, such as protein expression, and physiological changes under different disease states. Thus, this review aims to report recent progress in the use of PK-PD modeling to predict cardiovascular toxicities, as well as its application in anti-cancer therapies.
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