4.6 Article

Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner

Related references

Note: Only part of the references are listed.
Article Oncology

Stem signatures associated antibodies yield early diagnosis and precise prognosis predication of patients with non-small cell lung cancer

Si-Si Chen et al.

Summary: The stem signatures associated antibodies MAGEA1, PGP9.5, SOX2, and TP53 showed high expressions in NSCLC, negatively correlating with overall survival. These antibodies exhibited high specificity and sensitivity in early diagnosis, presenting potential applications in clinical practice.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

Article Medicine, Research & Experimental

Lung cancer pathogenesis and poor response to therapy were dependent on driver oncogenic mutations

Xin Sun et al.

Summary: The study revealed that smoking stimulated oncogenic gene mutations, with EGFR, KRAS, and TP53 being the most frequently mutated genes. The N stage of patients with E/K/P mutations affected survival prognosis, while radiation did not benefit patients in stage II/III and did not extend survival in patients with mutation burdens.

LIFE SCIENCES (2021)

Article Cell Biology

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Bas Ponsioen et al.

Summary: The study illustrates how EGFR activity enhances signal transduction efficiency in KRAS or BRAF mutant MAPK pathways, revealing a potential mechanism for using EGFR inhibitors in colorectal cancer with KRAS and BRAF mutations.

NATURE CELL BIOLOGY (2021)

Article Medicine, General & Internal

Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC

S. S. Ramalingam et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Genetics & Heredity

The Biogenesis and Precise Control of RNA m6A Methylation

Huilin Huang et al.

TRENDS IN GENETICS (2020)

Article Cell & Tissue Engineering

Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis

Wenju Chang et al.

CELL STEM CELL (2020)

Article Medicine, Research & Experimental

m6A Methylation of Precursor-miR-320/RUNX2 Controls Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells

Gege Yan et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Review Oncology

m6A-binding proteins: the emerging crucial performers in epigenetics

Yanchun Zhao et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Review Biochemistry & Molecular Biology

The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs

Lele Zhang et al.

MOLECULAR CANCER (2020)

Article Biochemical Research Methods

TISIDB: an integrated repository portal for tumor-immune system interactions

Beibei Ru et al.

BIOINFORMATICS (2019)

Review Biochemistry & Molecular Biology

The role of m6A RNA methylation in human cancer

Xiao-Yu Chen et al.

MOLECULAR CANCER (2019)

Review Oncology

Tobacco and the lung cancer epidemic in China

Mark Parascandola et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2019)

Review Oncology

The interplay between m6A RNA methylation and noncoding RNA in cancer

Shuai Ma et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Review Behavioral Sciences

The emerging role of mRNA methylation in normal and pathological behavior

M. Engel et al.

GENES BRAIN AND BEHAVIOR (2018)

Article Oncology

Acquired resistance in oncogene-addicted non-small-cell lung cancer

Claudio Sini et al.

FUTURE ONCOLOGY (2018)

Article Biochemistry & Molecular Biology

METTL3-mediated m6 A modification is required for cerebellar development

Chen-Xin Wang et al.

PLOS BIOLOGY (2018)

Article Biotechnology & Applied Microbiology

Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells

X. Sun et al.

CANCER GENE THERAPY (2016)

Review Cell Biology

The insights of Let-7 miRNAs in oncogenesis and stem cell potency

Xin Sun et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2016)

Article Oncology

Five-Year Survival in EGFR-Mutant Metastatic Lung Adenocarcinoma Treated with EGFR-TKIs

Jessica J. Lin et al.

JOURNAL OF THORACIC ONCOLOGY (2016)

Review Multidisciplinary Sciences

Cancer prevention and control: alarming challenges in China

Ann M. Bode et al.

NATIONAL SCIENCE REVIEW (2016)

Review Oncology

Resisting Resistance: Targeted Therapies in Lung Cancer

Jessica J. Lin et al.

TRENDS IN CANCER (2016)

Review Oncology

Prevention and management of lung cancer in China

Qun-Ying Hong et al.

CANCER (2015)

Article Cell Biology

DICER1 regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1

Xin Sun et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2015)