Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.761379
Keywords
oral squamous cell carcinoma; cisplatin; chemoresistance; molecular mechanisms; cancer therapy
Categories
Funding
- Postdoctoral Science Foundation of China [2017M622145]
- Natural Science Foundation of Shandong Province [ZR2018BH021]
- Science and Technology Project of Qingdao West Coast New Area [2019-60]
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Oral squamous cell carcinoma is a malignant tumor with low survival rate and high risk of metastasis and recurrence. Cisplatin-based chemotherapy is considered as the first-line treatment, but resistance to cisplatin limits its efficacy. This review outlines the mechanisms of cisplatin resistance and strategies to overcome it.
Oral squamous cell carcinoma (OSCC) is a kind of malignant tumors with low survival rate and prone to have early metastasis and recurrence. Cisplatin is an alkylating agent which induces DNA damage through the formation of cisplatin-DNA adducts, leading to cell cycle arrest and apoptosis. In the management of advanced OSCC, cisplatin-based chemotherapy or chemoradiotherapy has been considered as the first-line treatment. Unfortunately, only a portion of OSCC patients can benefit from cisplatin treatment, both inherent resistance and acquired resistance greatly limit the efficacy of cisplatin and even cause treatment failure. Herein, this review outline the underlying mechanisms of cisplatin resistance in OSCC from the aspects of DNA damage and repair, epigenetic regulation, transport processes, programmed cell death and tumor microenvironment. In addition, this review summarizes the strategies applicable to overcome cisplatin resistance, which can provide new ideas to improve the clinical therapeutic outcome of OSCC.
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