Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.721416
Keywords
head and neck squamous cell carcinoma; exosome; miR-185-3p; RAB25; tumor growth
Categories
Funding
- National Science Foundation [82071023]
- Henan Natural Science Foundation [202300410382]
- Youth Foundation of The First affiliated Hospital of ZhengZhou University
Ask authors/readers for more resources
The study reveals that exosomal miR-185-3p promotes tumor growth by mediating RAB25, which can be effectively targeted for HNSCC treatment. Targeting miR-185-3p/RAB25 significantly inhibits tumor growth and enhances drug response to chemotherapy.
Cancer cell-derived exosomes regulate tumor growth and progression. However, the effects of exosomes and its contents on head and neck squamous cell carcinoma (HNSCC) and its underlying mechanisms remain unclear. Here, we found HNSCC displayed a dysregulation of exosomes biogenesis. miR-185-3p was one of the most upregulated exosome-derived miRNAs in HNSCC. Functional assay showed that RAB25 is a direct downstream target of miR-185-3p. miR-185-3p/RAB25 signaling controlled tumor progression and correlated with disease prognosis. Targeting miR-185-3p/RAB25 significantly inhibited tumor growth and promoted drug response to chemotherapy. To conclude, the findings demonstrate exosomal miR-185-3p promotes tumor growth by mediating RAB25 that could be effectively targeted for HNSCC treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available