Journal
CANCER BIOLOGY & MEDICINE
Volume 19, Issue 2, Pages 163-174Publisher
CHINA ANTI-CANCER ASSOC
DOI: 10.20892/j.issn.2095-3941.2021.0461
Keywords
Cancer metabolism; diet intervention; carbohydrate; amino acid; lipid
Categories
Funding
- National Key R&D Program of China [2020YFA0803402, 2019YFA0801703]
- Natural Science Foundation of China [81790250/81790253, 91959202, 82121004, 81872240]
- Innovation Program of Shanghai Municipal Education Commission [N173606]
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Metabolic remodeling is a key feature in cancer development, leading malignant cells to favor specialized fermentation. Targeted cancer therapies based on reprogramming nutrient or metabolite metabolism have gained substantial attention, as well as the management of nutrient availability becoming more appealing.
Metabolic remodeling is a key feature of cancer development. Knowledge of cancer metabolism has greatly expanded since the first observation of abnormal metabolism in cancer cells, the so-called Warburg effect. Malignant cells tend to modify cellular metabolism to favor specialized fermentation over the aerobic respiration usually used by most normal cells. Thus, targeted cancer therapies based on reprogramming nutrient or metabolite metabolism have received substantial attention both conceptually and in clinical practice. In particular, the management of nutrient availability is becoming more attractive in cancer treatment. In this review, we discuss recent findings on tumor metabolism and potential dietary interventions based on the specific characteristics of tumor metabolism. First, we present a comprehensive overview of changes in macronutrient metabolism. Carbohydrates, amino acids, and lipids, are rewired in the cancer microenvironment individually or systematically. Second, we summarize recent progress in cancer interventions applying different types of diets and specific nutrient restrictions in pre-clinical research or clinical trials.
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