Journal
ADVANCED MATERIALS TECHNOLOGIES
Volume 7, Issue 1, Pages -Publisher
WILEY
DOI: 10.1002/admt.202100947
Keywords
3D bioprinting; decellularized extracellular matrix; microfabrication; photocatalytic crosslinking; tissue engineering
Categories
Funding
- Ministry of Trade, Industry and Energy (MOTIE)
- Korea Institute for Advancement of Technology (KIAT) through the International Cooperative RD program
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT (MSIT) [2021R1A2C2004981]
- National Research Foundation of Korea [2021R1A2C2004981] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The concept of microtissues has evolved to create human tissue analogs with physiologically relevant features for advanced therapeutic development. Optimizing biomaterial manufacturing enhances tissue modeling and biofunctional attributes. Developed method utilizing dERS enables single-step bioprinting for microtissue production, promoting tissue maturation and print fidelity.
The concept of microtissues has evolved to adapt to the generation of human tissue analogs that mimic physiologically relevant morphological and functional features. These microtissues can provide an in vitro testing platform for the development of advanced therapeutic options. Optimizing the manufacturing process of biomaterials brings several great benefits to achieve the desired mechanical, chemical, and biological properties for tissue modeling. Hence, 3D bioprinting technology has been utilized to fabricate functional microtissues. However, current microtissue bioprinting systems still require a cumbersome and time-consuming task, such as washing, which renders it difficult to maintain the shape of intact constructs, thereby resulting in inappropriate tissue morphogenesis. To overcome this limitation, a single-step bioprinting method is developed easier and more versatile for microtissue production based on a dual-crosslinkable decellularized extracellular matrix with ruthenium/sodium persulfate (dERS). The developed method enables the fabrication of spheroidal and tubular microstructures into a medium chamber, followed by the immediate culturing of printed structures without multiple postprocesses. The structural characteristics can be controlled by adjusting the printing parameters. Each dERS-based microtissue promotes tissue maturation and exhibits biofunctional attributes. These results suggest that the developed method may enable the simultaneous achievement of adequate print fidelity and tissue functionality.
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