Journal
ADVANCED MATERIALS TECHNOLOGIES
Volume 7, Issue 9, Pages -Publisher
WILEY
DOI: 10.1002/admt.202101425
Keywords
biochemical sensing; flexible plasmonics; LSPR; metal-enhanced fluorescence; swelling hydrogels
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Funding
- CNR@Projects [SAC.AD002.173.026 TIPPS]
- Consiglio Nazionale delle Ricerche within the CRUI-CARE Agreement
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A hybrid plasmonic transducer made of a Poly-(ethylene glycol) diacrylate (PEGDA) hydrogel and citrate gold nanoparticles is able to detect the biotin-streptavidin interaction at picomolar concentrations. The fabrication strategy is large-scale, tunable, and low-cost. The device is highly reproducible and optically stable, and it can be used in dual-optical mode.
A hybrid plasmonic transducer made of a Poly-(ethylene glycol) diacrylate (PEGDA) hydrogel and citrate gold nanoparticles detects the biotin-streptavidin interaction at picomolar (x 10(-12) m ) concentrations. The all-solution fabrication strategy, herein proposed, is large-scale, easily tunable, and low-cost; nevertheless, this innovative device is highly reproducible and optically stable, and it can be used in dual-optical mode. Indeed, both metal-enhanced fluorescence and localized surface plasmon resonance signals can be exploited to quantify the biorecognition process in a 3D architecture. The large swelling capability of high molecular weight PEGDA is used to investigate the plasmon absorption variations resulting from the exposure to biological solutions containing high molecular weight molecules within the 3D network. The proposed transducer represents a low-cost, flexible, and easy-to-use platform for sensing applications in biomedical or environmental diagnostics.
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