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Targeting the Undruggable Proteome: The Small Molecules of My Dreams
Craig M. Crews
CHEMISTRY & BIOLOGY (2010)
IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation
Giovanni Benard et al.
EMBO JOURNAL (2010)
Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest
Margaret E. Harley et al.
EMBO JOURNAL (2010)
The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid
Bilal A. Azakir et al.
FEBS JOURNAL (2010)
Sept4/ARTS is required for stem cell apoptosis and tumor suppression
Maria Garcia-Fernandez et al.
GENES & DEVELOPMENT (2010)
Protein Knockdown Using Methyl Bestatin-Ligand Hybrid Molecules: Design and Synthesis of Inducers of Ubiquitination-Mediated Degradation of Cellular Retinoic Acid-Binding Proteins
Yukihiro Itoh et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Multistep and multitask Bax activation
Lina Ghibelli et al.
MITOCHONDRION (2010)
MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases
Jennifer M. Doyle et al.
MOLECULAR CELL (2010)
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
Ping-Hui Tseng et al.
NATURE IMMUNOLOGY (2010)
Mitochondria and cell death: outer membrane permeabilization and beyond
Stephen W. G. Tait et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
The C terminus of p53 binds the N-terminal domain of MDM2
Masha V. Poyurovsky et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression
Sean L. Petersen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer
Mads Gyrd-Hansen et al.
NATURE REVIEWS CANCER (2010)
Can't live without them, can live with them: roles of caspases during vital cellular processes
Yael Feinstein-Rotkopf et al.
APOPTOSIS (2009)
Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
Francesco Parlati et al.
BLOOD (2009)
Ursolic Acid Triggers Apoptosis and Bcl-2 Downregulation in MCF-7 Breast Cancer Cells
E. Kassi et al.
CANCER INVESTIGATION (2009)
Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
Sudan He et al.
CELL (2009)
Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation
Ping Xu et al.
CELL (2009)
Regulation of cell death by the ubiquitin-proteasome system
Maya Bader et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
The Lysine 48 and Lysine 63 Ubiquitin Conjugates Are Processed Differently by the 26 S Proteasome
Andrew D. Jacobson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Proliferation defects and genome instability in cells lacking Cul4A
D. Kopanja et al.
ONCOGENE (2009)
Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation
Nitzan Shabek et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation
Luyang Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Trim24 targets endogenous p53 for degradation
Kendra Allton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Ubiquitin-mediated regulation of apoptosis
Melke Broemer et al.
TRENDS IN CELL BIOLOGY (2009)
Apoptosis and cancer: the genesis of a research field
Thomas G. Cotter
NATURE REVIEWS CANCER (2009)
Targeting cancer with small molecule kinase inhibitors
Jianming Zhang et al.
NATURE REVIEWS CANCER (2009)
The first 30 years of p53: growing ever more complex
Arnold J. Levine et al.
NATURE REVIEWS CANCER (2009)
Design of Small-Molecule Peptidic and Nonpeptidic Smac Mimetics
Haiying Sun et al.
ACCOUNTS OF CHEMICAL RESEARCH (2008)
Inhibitors of apoptosis catch ubiquitin: Figure 1
Krishnaraj Rajalingam et al.
BIOCHEMICAL JOURNAL (2008)
Molecular basis of bortezomib resistance:: proteasome subunit β5 (PSMB5) gene mutation and overexpression of PSMB5 protein
Ruud Oerlemans et al.
BLOOD (2008)
TNF-α induces two distinct caspase-8 activation pathways
Lai Wang et al.
CELL (2008)
Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
K. Linke et al.
CELL DEATH AND DIFFERENTIATION (2008)
Regulation of apoptosis in Drosophila
H. Steller
CELL DEATH AND DIFFERENTIATION (2008)
p53: A guide to apoptosis
Erik Meulmeester et al.
CURRENT CANCER DRUG TARGETS (2008)
Ubiquitin-proteasome system as a modulator of cell fate
Simon J. Thompson et al.
CURRENT OPINION IN PHARMACOLOGY (2008)
Atypical ubiquitin chains: new molecular signals - 'Protein modifications: Beyond the usual suspects' review series
Fumiyo Ikeda et al.
EMBO REPORTS (2008)
Regulation of apoptosis by XIAP ubiquitin-ligase activity
Andrew J. Schile et al.
GENES & DEVELOPMENT (2008)
c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation
Eugene Varfolomeev et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Caspase-mediated Bak Activation and Cytochrome c Release during Intrinsic Apoptotic Cell Death in Jurkat Cells
Mary E. Shawgo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
IAPs: What's in a name?
Srinivasa M. Srinivasula et al.
MOLECULAR CELL (2008)
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
Mathieu J. M. Bertrand et al.
MOLECULAR CELL (2008)
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis
Mads Gyrd-Hansen et al.
NATURE CELL BIOLOGY (2008)
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling
Sivakumar Vallabhapurapu et al.
NATURE IMMUNOLOGY (2008)
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Regulation of TNFR1 and CD95 signalling by receptor compartmentalization
Stefan Schuetze et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex
Atsushi Matsuzawa et al.
SCIENCE (2008)
CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib
Roberto Piva et al.
BLOOD (2008)
Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL
Feng-Ting Liu et al.
BLOOD (2008)
Peroxide is a key mediator of Bcl-2 down-regulation and apoptosis induction by cisplatin in human lung cancer cells
Liying Wang et al.
MOLECULAR PHARMACOLOGY (2008)
Increased expression and altered subunit composition of proteasomes induced by continuous proteasome inhibition establish apoptosis resistance and hyperproliferation of Burkitt lymphoma cells
Dominik Fuchs et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2008)
Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP
John C. Wilkinson et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-α signaling
Alex Gaither et al.
CANCER RESEARCH (2007)
IAPs as a target for anticancer therapy
S. Danson et al.
CURRENT CANCER DRUG TARGETS (2007)
IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis
Eugene Varfolomeev et al.
CELL (2007)
IAP antagonists target cIAP1 to induce TNFα- dependent apoptosis
James E. Vince et al.
CELL (2007)
Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target
Nitzan Shabek et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Autocrine TNFα signaling renders human cancer cells susceptible to smac-mimetic-induced apoptosis
Sean L. Petersen et al.
CANCER CELL (2007)
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myelorna
Deborah J. Kuhn et al.
BLOOD (2007)
Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancer
Irene Esposito et al.
JOURNAL OF CLINICAL PATHOLOGY (2007)
Regulation of receptors and transporters by ubiquitination: New insights into surprisingly similar mechanisms
Manuel Miranda et al.
MOLECULAR INTERVENTIONS (2007)
Degradation of Mcl-1 by β-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization
Qingqing Ding et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2
Rajesh K. Singh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
CARPs are ubiquitin Ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation
Wensheng Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Proteasome-independent functions of ubiquitin in endocytosis and signaling
Debdyuti Mukhopadhyay et al.
SCIENCE (2007)
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
Masha V. Poyurovsky et al.
EMBO JOURNAL (2007)
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'
Satoshi Yamasaki et al.
EMBO JOURNAL (2007)
Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination
Erina Kuranaga et al.
TRENDS IN CELL BIOLOGY (2007)
KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction
Koji Okamoto et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Opinion - How many drug targets are there?
John P. Overington et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway
L. Ma et al.
CELL DEATH AND DIFFERENTIATION (2006)
Narrative review: Protein degradation and human diseases: The ubiquitin connection
Eyal Reinstein et al.
ANNALS OF INTERNAL MEDICINE (2006)
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family
Brendan P. Eckelman et al.
EMBO REPORTS (2006)
L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes
Damon Banks et al.
CELL CYCLE (2006)
Ubiquitin ligases: cell-cycle control and cancer
KI Nakayama et al.
NATURE REVIEWS CANCER (2006)
The apoptosome activates caspase-9 by dimerization
C Pop et al.
MOLECULAR CELL (2006)
Structure and interactions of the helical and U-box domains of CHIP, the C terminus of HSP70 interacting protein
Z Xu et al.
BIOCHEMISTRY (2006)
Development of peptidomimetics targeting IAPs
SK Sharma et al.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS (2006)
The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases
BP Eckelman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis
SA Lakhani et al.
SCIENCE (2006)
Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1
WH Yin et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases
T Samuel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs
Kerry Zobel et al.
ACS CHEMICAL BIOLOGY (2006)
Structural details on mdm2-p53 interaction
SW Chi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
D Chauhan et al.
CANCER CELL (2005)
BH3-ligand regulates access of MCL-1 to its E3 ligase
MR Warr et al.
FEBS LETTERS (2005)
Ubiquitylation and cell signaling
K Haglund et al.
EMBO JOURNAL (2005)
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation
CG Wang et al.
EMBO JOURNAL (2005)
The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation
C Esser et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The ubiquitin-proteasome pathway and its role in cancer
A Mani et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells
JZ Qin et al.
CANCER RESEARCH (2005)
Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation
R Lotan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
Q Zhong et al.
CELL (2005)
ARF-BP1/mule is a critical mediator of the ARF tumor suppressor
DL Chen et al.
CELL (2005)
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
T Hideshima et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
SN Willis et al.
GENES & DEVELOPMENT (2005)
Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane
L Burri et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
IAPs, RINGs and ubiquitylation
DL Vaux et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DLABLO
Y Morizane et al.
JOURNAL OF BIOCHEMISTRY (2005)
Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells
QH Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The mitochondrial ARTS protein promotes apoptosis through targeting XIAP
Y Gottfried et al.
EMBO JOURNAL (2004)
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
LT Vassilev et al.
SCIENCE (2004)
A small molecule Smac mimic potentiates TRAIL- and TNFα-mediated cell death
L Li et al.
SCIENCE (2004)
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
R Rajendra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer
TK Oost et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
p53 upregulates death receptor 4 expression through an intronic p53 binding site
XG Liu et al.
CANCER RESEARCH (2004)
Structure-based design of potent, conformationally constrained Smac mimetics
HY Sun et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients
R Elhasid et al.
ONCOGENE (2004)
The proteasome: a proteolytic nanomachine of cell regulation and waste disposal
DH Wolf et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)
Cul4A physically associates with MDM2 and participates in the proteolysis of p53
A Nag et al.
CANCER RESEARCH (2004)
Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins
EM Creagh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The two NF-κB activation pathways and their role in innate and adaptive immunity
G Bonizzi et al.
TRENDS IN IMMUNOLOGY (2004)
Inhibitor of apoptosis proteins: Translating basic knowledge into clinical practice
AD Schimmer
CANCER RESEARCH (2004)
The ubiquitin ligase COP1 is a critical negative regulator of p53
D Dornan et al.
NATURE (2004)
Control of apoptosis by p53
JS Fridman et al.
ONCOGENE (2003)
Regulators of IAP function: coming to grips with the grim reaper
A Bergmann et al.
CURRENT OPINION IN CELL BIOLOGY (2003)
The Bcl-2 family: roles in cell survival and oncogenesis
S Cory et al.
ONCOGENE (2003)
Structural insights into the U-box, a domain associated with multi-ubiquitination
MD Ohi et al.
NATURE STRUCTURAL BIOLOGY (2003)
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation
RP Leng et al.
CELL (2003)
Inhibiting the p53-MDM2 interaction:: An important target for cancer therapy
P Chène
NATURE REVIEWS CANCER (2003)
Bcl-2-family proteins and the role of mitochondria in apoptosis
T Kuwana et al.
CURRENT OPINION IN CELL BIOLOGY (2003)
Structure and zymogen activation of caspases
M Donepudi et al.
BIOPHYSICAL CHEMISTRY (2002)
Proteasome-mediated degradation of Smac during apoptosis:: XIAP promotes Smac ubiquitination in vitro
M MacFarlane et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis
DW Leaman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
D Migliorini et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis
R Wilson et al.
NATURE CELL BIOLOGY (2002)
IAP proteins: Blocking the road to death's door
GS Salvesen et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
XM Li et al.
NATURE (2002)
Identification of Omi/HtrA-2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction
R Hegde et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity
G van Loo et al.
CELL DEATH AND DIFFERENTIATION (2002)
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2
C Adrain et al.
EMBO JOURNAL (2001)
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism, involving a Cullin-containing complex
E Querido et al.
GENES & DEVELOPMENT (2001)
CHIP is a U-box-dependent E3 ubiquitin ligase -: Identification of Hsc70 as a target for ubiquitylation
JH Jiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms
R Stad et al.
EMBO REPORTS (2001)
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
J Parant et al.
NATURE GENETICS (2001)
X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and-7 in distinct modes
Y Suzuki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Plasma cell differentiation requires the transcription factor XBP-1
AM Reimold et al.
NATURE (2001)
Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
KM Sakamoto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
Y Suzuki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
The RHG motifs of Drosophila Reaper and Grim are important for their distinct cell death-inducing abilities
JP Wing et al.
MECHANISMS OF DEVELOPMENT (2001)
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
SM Srinivasula et al.
NATURE (2001)
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
ZH Liu et al.
NATURE (2000)
Structural basis of IAP recognition by Smac/DIABLO
G Wu et al.
NATURE (2000)
A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif
S Larisch et al.
NATURE CELL BIOLOGY (2000)
ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas
D Vucic et al.
CURRENT BIOLOGY (2000)
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
JJ Chai et al.
NATURE (2000)
The contribution of the RING finger domain of MDM2 to cell cycle progression
M Argentini et al.
ONCOGENE (2000)
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
CY Du et al.
CELL (2000)
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
AM Verhagen et al.
CELL (2000)
Nora, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
E Oda et al.
SCIENCE (2000)
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
Y Yang et al.
SCIENCE (2000)
Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression
BY Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
SY Fang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Activity of MDM2, a ubiquitin Ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
R Honda et al.
ONCOGENE (2000)
Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
L Goyal et al.
EMBO JOURNAL (2000)
The role of p53-target genes in human cancer
T Tokino et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2000)
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