4.6 Article

Shear Stress Alterations Activate BMP4/pSMAD5 Signaling and Induce Endothelial Mesenchymal Transition in Varicose Veins

Related references

Note: Only part of the references are listed.
Article Surgery

Transforming growth factor-β1 and inducible nitric oxide synthase signaling were involved in effects of prostaglandin E2 on progression of lower limb varicose veins

Ji-Chang Wang et al.

Summary: The vital pathogenesis of varicose veins involves extracellular matrix remodeling and decreased vascular tone. Prostaglandin E-2 (PGE(2)) plays a role in influencing metalloproteinase expression and vascular tone in the development of varicose veins. The study found that PGE(2) can promote migration and tube formation in endothelial cells, upregulate the expression of MMP-1 and TGF-beta 1, and increase the mRNA level of inducible NOS, potentially leading to extracellular matrix remodeling and reduced vascular wall elasticity.

JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS (2021)

Review Endocrinology & Metabolism

The role of bone morphogenetic protein signaling in vascular calcification

Peiran Yang et al.

Article Biochemistry & Molecular Biology

LncRNA MALAT1 modulates ox-LDL induced EndMT through the Wnt/-catenin signaling pathway

Hongrong Li et al.

LIPIDS IN HEALTH AND DISEASE (2019)

Article Multidisciplinary Sciences

Venous identity requires BMP signalling through ALK3

Alice Neal et al.

NATURE COMMUNICATIONS (2019)

Review Cardiac & Cardiovascular Systems

Endothelial-mesenchymal transition in atherosclerosis

Celine Souilhol et al.

CARDIOVASCULAR RESEARCH (2018)

Article Biochemistry & Molecular Biology

Endovascular Interventions Permit Isolation of Endothelial Colony-Forming Cells from Peripheral Blood

Vera Matveeva et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Chronic Venous Insufficiency: Transforming Growth Factor-β Isoforms and Soluble Endoglin Concentration in Different States of Wound Healing

Daniela Ligi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Medicine, Research & Experimental

Arterialization and anomalous vein wall remodeling in varicose veins is associated with upregulated FoxC2-DII4 pathway

Sumi Surendran et al.

LABORATORY INVESTIGATION (2016)

Article Cell Biology

TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

Masato Morikawa et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress

Jan-Renier A. J. Moonen et al.

CARDIOVASCULAR RESEARCH (2015)

Article Cardiac & Cardiovascular Systems

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

Benoit Ranchoux et al.

CIRCULATION (2015)

Article Surgery

Epidemiological Study on Chronic Venous Disease in Belgium and Luxembourg: Prevalence, Risk Factors, and Symptomatology

M. E. Vuylsteke et al.

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY (2015)

Article Cell Biology

TGF-β Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling

Brian C. Cooley et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Hematology

The Role of Shear-Induced Transforming Growth Factor-β Signaling in the Endothelium

Tony E. Walshe et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

Article Multidisciplinary Sciences

A New Class of Small Molecule Inhibitor of BMP Signaling

Caroline E. Sanvitale et al.

PLOS ONE (2013)

Article Cell Biology

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation

Jessica L. Allen et al.

MOLECULAR BIOLOGY OF THE CELL (2012)

Article Multidisciplinary Sciences

Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow

Jing Zhou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Bone morphogenetic protein 4 stimulates neuronal differentiation of neuronal stem cells through the ERK pathway

Byoung-San Moon et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2009)

Article Physiology

TGF-beta(1) upregulation in the aging varicose vein

Gemma Pascual et al.

JOURNAL OF VASCULAR RESEARCH (2007)

Article Hematology

Flow effects on coagulation and thrombosis

James J. Hathcock

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

Review Cardiac & Cardiovascular Systems

Chronic venous insufficiency

RT Eberhardt et al.

CIRCULATION (2005)

Article Biochemistry & Molecular Biology

Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response

GP Sorescu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)