Journal
CELLS
Volume 10, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/cells10102752
Keywords
TFEB; autophagy; mTOR; AMPK; lysosomes; cancer; nanoparticles
Categories
Funding
- IIT Kanpur
- Center grant from Autophagy Inflammation and Metabolism center, University of New Mexico
- Comunidad de Madrid [IND2017/IND-7809]
- IMDEA Nanociencia
- italian Ministry for Health (Ricerca Corrente) [000003_17_MAP_STRIP, FISR 2020-Covid FISR2020IP_03366]
- Ramon y Cajal tenure track contract from the spanish Ministry of Science and Innovation [RYC2020-029690-I]
- 'Severo Ochoa' Programme for Centres of Excellence in RD (MINECO) [SEV-2016-0686]
- Instituto de Salud Carlos III (ISCIII)
- Ministerio de Ciencia e Innovacion (MCIN)
- Pro CNIC Foundation
- italian Ministry for Education, University and Research (MIUR) [000003_17_MAP_STRIP, FISR 2020-Covid FISR2020IP_03366]
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Autophagy and the lysosomal system, known together as the autophagolysosomal system, play a crucial role in maintaining cellular health and homeostasis by clearing cellular waste. TFEB regulates this system by driving the expression of multiple genes, including components of the autophagolysosomal system. Reactive Oxygen Species (ROS) are key in the physiological and pathological roles of this system.
Autophagy and the lysosomal system, together referred to as the autophagolysosomal system, is a cellular quality control network which maintains cellular health and homeostasis by removing cellular waste including protein aggregates, damaged organelles, and invading pathogens. As such, the autophagolysosomal system has roles in a variety of pathophysiological disorders, including cancer, neurological disorders, immune- and inflammation-related diseases, and metabolic alterations, among others. The autophagolysosomal system is controlled by TFEB, a master transcriptional regulator driving the expression of multiple genes, including autophagoly sosomal components. Importantly, Reactive Oxygen Species (ROS) production and control are key aspects of the physiopathological roles of the autophagolysosomal system, and may hold a key for synergistic therapeutic interventions. In this study, we reviewed our current knowledge on the biology and physiopathology of the autophagolysosomal system, and its potential for therapeutic intervention in cancer.
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