Journal
CELLS
Volume 10, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/cells10112945
Keywords
diabetes; diabetic kidney disease; mitochondria; bioenergetics; redox status
Categories
Funding
- AMERICAN HEART ASSOCIATION [18AIREA33990023]
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Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in the USA, with a multifactorial pathogenesis involving activation of multiple signaling pathways that lead to various pathological changes, mainly driven by alterations in mitochondrial bioenergetics. Understanding the role of bioenergetics in the progression of DKD may offer novel therapeutic approaches to delay progression to ESRD.
Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in the USA. The pathogenesis of DKD is multifactorial and involves activation of multiple signaling pathways with merging outcomes including thickening of the basement membrane, podocyte loss, mesangial expansion, tubular atrophy, and interstitial inflammation and fibrosis. The glomerulo-tubular balance and tubule-glomerular feedback support an increased glomerular filtration and tubular reabsorption, with the latter relying heavily on ATP and increasing the energy demand. There is evidence that alterations in mitochondrial bioenergetics in kidney cells lead to these pathologic changes and contribute to the progression of DKD towards ESRD. This review will focus on the dialogue between alterations in bioenergetics in glomerular and tubular cells and its role in the development of DKD. Alterations in energy substrate selection, electron transport chain, ATP generation, oxidative stress, redox status, protein posttranslational modifications, mitochondrial dynamics, and quality control will be discussed. Understanding the role of bioenergetics in the progression of diabetic DKD may provide novel therapeutic approaches to delay its progression to ESRD.
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