Journal
CELLS
Volume 10, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/cells10123529
Keywords
glioblastoma; metabolism; microenvironment
Categories
Funding
- Instituto de Salud Carlos III [ISCIII CM19/00068, ISCIII AES-2019/001217]
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This review discusses how genetic alterations and metabolism pathways in Glioblastoma (GBM) influence tumor immune cells and the tumor microenvironment, and provides an overview of the strategies being tested.
Glioblastoma (GBM) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping this tumor microenvironment (TME) regulate tumor initiation, progression, and treatment response. Genetic alterations and metabolism pathways are two main elements that influence tumor immune cells and TME. In this manuscript, we review how both factors can contribute to an immunosuppressive state and overview the strategies being tested.
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