4.6 Review

The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease

Related references

Note: Only part of the references are listed.
Review Obstetrics & Gynecology

Animal models of preeclampsia: investigating pathophysiology and therapeutic targets

Bhavisha A. Bakrania et al.

Summary: Animal models play a critical role in investigating the pathogenesis and treatment options for preeclampsia. They allow researchers to study the detailed mechanisms of this disease and are important tools in the search for novel therapies.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2022)

Article Developmental Biology

Placental characteristics and risks of maternal mortality 50 years after delivery

E. H. Yeung et al.

Summary: The study found that placental weight in relation to birthweight is associated with long-term maternal mortality, but other histopathologic or morphologic features are not.

PLACENTA (2022)

Review Obstetrics & Gynecology

The Placenta's Role in Sexually Dimorphic Fetal Growth Strategies

Julian K. Christians

Summary: Fetal sex impacts pregnancy complications and long-term health effects of prenatal environment, with placenta playing a crucial role. Sexual dimorphism may affect gene expression, responses to nutrient supply, and histopathology, but there is no clear pattern supporting the hypothesis that one sex is more responsive. More robust statistical approaches are needed to test for sex-dependent effects in order to reduce spurious results.

REPRODUCTIVE SCIENCES (2022)

Article Medical Laboratory Technology

Consensus Definition of Fetal Growth Restriction in Intrauterine Fetal Death A Delphi Procedure

Irene Maria Beune et al.

Summary: This study established a consensus-based definition for fetal growth restriction in fetal death through a modified online Delphi survey with an international panel of experts. The consensus definition included antenatal clinical diagnosis, birth weight criteria, and contributory variables, aiming to improve management and outcomes of subsequent pregnancies.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2021)

Article Reproductive Biology

Intrauterine growth restriction: Clinical consequences on health and disease at adulthood

J. B. Armengaud et al.

Summary: Intrauterine growth restriction (IUGR) can result from maternal, placental, or fetal factors, with maternal malnutrition before and during pregnancy being the most common cause. Individuals born after IUGR are more susceptible to developing diseases in adulthood.

REPRODUCTIVE TOXICOLOGY (2021)

Article Biochemistry & Molecular Biology

Central role of the placenta during viral infection: Immuno-competences and miRNA defensive responses

Veronica Zaga-Clavellina et al.

Summary: During pregnancy, an immunological dialogue is established between maternal immune cells and trophoblasts to protect the fetus from rejection. The maternal-placental-fetal interface plays a crucial role in this defense. Research focuses on viral infections affecting the placenta and trophoblasts, along with their defensive mechanisms.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

Review Medicine, Research & Experimental

An integrative look at SARS-CoV-2 (Review)

Miguel A. Ortega et al.

Summary: SARS-CoV-2, the etiological agent of COVID-19 pandemic, shows higher infectivity and mortality compared to previous coronaviruses. Its aggressive nature stems from its ability to easily infect and spread through interaction with human ACE-2 receptor. The diverse patient responses highlight the importance of immune system function, with overactive responses potentially leading to severe cases. Developing therapies and vaccines to regulate immune response will be crucial in managing clinical outcomes and reducing transmission of the virus.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

Review Biochemistry & Molecular Biology

Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia

Paul Guerby et al.

Summary: Preeclampsia is a pregnancy disease exclusive to humans, characterized by gestational hypertension, proteinuria, oxidative stress, and imbalance between NO and ROS production, possibly due to placental abnormalities and oxidative stress.

REDOX BIOLOGY (2021)

Article Developmental Biology

A re-examination of the origins of placental bed giant cells

Carolyn J. P. Jones et al.

Summary: Placental multinuclear giant cells are derived from trophoblastic elements, connected to extravillous cytotrophoblast cells, and formed as a terminal differentiation step during invasion stages, reducing the invasive population.

PLACENTA (2021)

Review Immunology

Maternal natural killer cells at the intersection between reproduction and mucosal immunity

Evgeniya V. Shmeleva et al.

Summary: During pregnancy, the decidua contains many maternal immune cells, including abundant NK cells and macrophages, which help the uterus adapt to fetal demands for nutrients and oxygen, supporting fetal growth. These immune cells not only have homeostatic functions, but can also respond to infections, potentially creating conflicts between destroying pathogens and sustaining placental growth.

MUCOSAL IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Hypoxia and oxidative stress induce sterile placental inflammation in vitro

Bernadette C. Baker et al.

Summary: Fetal growth restriction (FGR) and stillbirth are associated with placental dysfunction and inflammation, with oxidative and nitrative stress implicated in causing placental damage. Elevated levels of damage-associated molecular patterns (DAMPs) in high-risk pregnancies are linked to increased pro-inflammatory placental cytokines. In vitro exposure of placental tissue from uncomplicated pregnancies to hypoxia, oxidative, or nitrative stress resulted in differential release of DAMPs and pro-inflammatory cytokines. IL1 receptor antagonist (IL1Ra) treatment was shown to partially block hypoxia- and oxidative stress-induced placental inflammation, suggesting translational potential for preventing FGR and stillbirth-related placental inflammation.

SCIENTIFIC REPORTS (2021)

Review Immunology

Decidual Natural Killer Cells: A Good Nanny at the Maternal-Fetal Interface During Early Pregnancy

Yuefang Liu et al.

Summary: This review discusses the important roles of decidual natural killer (dNK) cells in pregnancy, highlighting their generation, subsets, surface or soluble molecules, and functions crucial for maintaining pregnancy. It also explores the new functions of dNK cells, such as controlled cytotoxicity, immunosurveillance, and immunotrophism, and the molecular mechanisms involved in these functions, emphasizing their potential clinical applications.

FRONTIERS IN IMMUNOLOGY (2021)

Review Obstetrics & Gynecology

Prenatal alcohol consumption and placental outcomes: a systematic review and meta-analysis of clinical studies

Sarah E. Steane et al.

Summary: The systematic review found that prenatal alcohol exposure increases the likelihood of placental abruption, decreases placental weight, and leads to changes in placental vasculature, DNA methylation, and molecular pathways. One study explored sex-specific placental outcomes in male and female infants separately. Further studies on the molecular mechanisms underlying alcohol-induced placental dysfunction and sex-specific placental adaptations are needed.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

Article Oncology

An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level

Miguel A. Ortega et al.

Summary: The study examined the changes in mRNA and protein expression levels of elastogenesis-related proteins in placental villi of women diagnosed with Chronic Venous Disease (CVD) during the third trimester of pregnancy. Results showed that CVD was associated with a significant decrease in EGFL7 expression, while an increase in ECM-related proteins was observed. This study provided insights into the role of EGFL7 in modulating elastogenesis in placental villi during pregnancy with CVD.

MOLECULAR MEDICINE REPORTS (2021)

Review Nutrition & Dietetics

A Systematic Review of Bisphenol A from Dietary and Non-Dietary Sources during Pregnancy and Its Possible Connection with Fetal Growth Restriction: Investigating Its Potential Effects and the Window of Fetal Vulnerability

Nikolaos Vrachnis et al.

Summary: A systematic review of 25 articles found mixed results on the relationship between BPA exposure and abnormal fetal growth, with most studies showing an inverse association. Evidence suggests that combined exposure to BPA from dietary and non-dietary sources during pregnancy may contribute to abnormal fetal growth, particularly in the first half of pregnancy.

NUTRIENTS (2021)

Article Multidisciplinary Sciences

Circulating EGFL7 distinguishes between IUGR and PE: an observational case-control study

Micol Massimiani et al.

Summary: EGFL7 levels in maternal blood show significant differences between isolated IUGR and PE pregnancies, particularly in early-onset PE cases. This suggests that EGFL7 could potentially be used as a biomarker for distinguishing between these two conditions.

SCIENTIFIC REPORTS (2021)

Review Pediatrics

The Immediate and Long-Term Impact of Preeclampsia on Offspring Vascular and Cardiac Physiology in the Preterm Infant

Annabelle L. Frost et al.

Summary: Hypertensive disorders of pregnancy, particularly preeclampsia, have significant long-term effects on maternal and offspring cardiovascular health. Offspring of preeclamptic pregnancies show altered cardiac structure and vascular physiology driven by lower endothelial function. There are knowledge gaps in understanding the relative contributions of prematurity and preeclampsia to the cardiovascular phenotype in offspring, warranting further research in the field.

FRONTIERS IN PEDIATRICS (2021)

Review Medicine, General & Internal

Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management

Miguel A. Ortega et al.

Summary: Chronic venous disease (CVD) is a multifactorial condition that affects a significant percentage of the global population, ranging from mild clinical signs to severe manifestations, with varicose veins being the most common form. Genetics and environmental factors play important roles in the development of CVD.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Biochemistry & Molecular Biology

Newborns of Mothers with Venous Disease during Pregnancy Show Increased Levels of Lipid Peroxidation and Markers of Oxidative Stress and Hypoxia in the Umbilical Cord

Miguel A. Ortega et al.

Summary: Pregnant women with chronic venous disease show a significant increase in oxidative stress and cellular damage in umbilical cord tissue, deepening the understanding of the consequences of this condition during pregnancy.

ANTIOXIDANTS (2021)

Article Medicine, General & Internal

Association Between Lower Extremity Venous Insufficiency and Intrapartum Fetal Compromise: A Nationwide Cross-Sectional Study

Angel Asunsolo et al.

Summary: The study found an association between varicose veins in women's lower extremities and/or pelvis and intrapartum fetal compromise, suggesting that varicose veins may be a novel and important clinical risk factor for fetal well-being and health.

FRONTIERS IN MEDICINE (2021)

Article Medicine, General & Internal

Influence of Cerebral Vasodilation on Blood Reelin Levels in Growth Restricted Fetuses

Jara Pascual-Mancho et al.

Summary: This study investigated the variation in Reelin levels in FGR newborns and their association with neurodevelopmental impairment. Results showed a significant association of elevated Reelin levels in FGR fetuses with cerebral blood redistribution compared to the normal weight group and the FGR with abnormal umbilical artery group. Future research should focus on expanding the knowledge of the relationship of Reelin and neurodevelopment impairment in FGR newborns.

DIAGNOSTICS (2021)

Review Obstetrics & Gynecology

Preeclampsia and late fetal growth restriction

Francesco Marasciulo et al.

Summary: The relationship between fetal growth restriction and preeclampsia is strong but complex, with the incidence of preeclampsia decreasing as gestation progresses. Different mechanisms underlie this trend, with placental and cardiovascular factors playing a role in late-onset fetal growth restriction. Screening strategies for placental dysfunction may not perform well for late-onset fetal growth restriction, particularly without preeclampsia.

MINERVA OBSTETRICS AND GYNECOLOGY (2021)

Article Medicine, General & Internal

Abnormal proinflammatory and stressor environmental with increased the regulatory cellular IGF-1/PAPP-A/ STC and Wnt-1/β-Catenin canonical pathway in placenta of women with Chronic venous Disease during Pregnancy

Miguel A. Ortega et al.

Summary: This study examined the genetic and protein expression in women with lower limbs venous insufficiency, revealing alterations in important pathways and factors such as IGF-1/PAPP-A/STC-2, PI3K/Akt, Wnt/beta-catenin, and inflammatory cytokines. These results contribute to the understanding of the association between venous insufficiency and placental damage, highlighting abnormal tissue environment and cellular regulation.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2021)

Article Physiology

Physical activity differentially regulates VEGF, PlGF, and their receptors in the human placenta

Jayonta Bhattacharjee et al.

Summary: Physical activity during pregnancy has beneficial effects on organ function and is associated with favorable outcomes for both mother and fetus. Researchers found that physically active women had significantly higher levels of VEGF and its receptor, VEGFR-1, in the placenta, suggesting that exercise may support a pro-angiogenic environment in the placental vascular network.

PHYSIOLOGICAL REPORTS (2021)

Article Obstetrics & Gynecology

PAPP-A concentrations change in patients with gestational diabetes

Raziye Caliskan et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2020)

Review Genetics & Heredity

The significance of the placental genome and methylome in fetal and maternal health

Giulia F. Del Gobbo et al.

HUMAN GENETICS (2020)

Article Cell Biology

Pregnancy-associated venous insufficiency course with placental and systemic oxidative stress

Miguel A. Ortega et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Article Immunology

The Status of Vaccine Development Against the Human Cytomegalovirus

Stanley A. Plotkin et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

Article Obstetrics & Gynecology

The Placenta as a Window to Maternal Vascular Health

W. Tony Parks et al.

OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA (2020)

Article Obstetrics & Gynecology

Fetal Membranes, Not a Mere Appendage of the Placenta, but a Critical Part of the Fetal-Maternal Interface Controlling Parturition

Ramkumar Merton et al.

OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA (2020)

Article Obstetrics & Gynecology

Immunology of the Placenta

Mancy Tong et al.

OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA (2020)

Article Obstetrics & Gynecology

Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia

Pooneh Nikuei et al.

BMC PREGNANCY AND CHILDBIRTH (2020)

Letter Immunology

Macrophage subsets at the maternal-fetal interface

Xiangxiang Jiang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Review Pharmacology & Pharmacy

The role of xenobiotic-metabolizing enzymes in the placenta: a growing research field

Ricardo Blanco-Castaneda et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

Increased Angiogenesis and Lymphangiogenesis in the Placental Villi of Women with Chronic Venous Disease during Pregnancy

Miguel A. Ortega et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Surgery

The 2020 update of the CEAP classification system and reporting standards

Fedor Lurie et al.

JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS (2020)

Review Multidisciplinary Sciences

Systematic review of prediction models for gestational hypertension and preeclampsia

Edward Antwi et al.

PLOS ONE (2020)

Article Biochemistry & Molecular Biology

Maternal malnutrition impacts placental morphology and transporter expression: an origin for poor offspring growth

Kristin L. Connor et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2020)

Article Multidisciplinary Sciences

First trimester PAPP-A serum levels and long-term metabolic outcome of mothers and their offspring

Arrigo Fruscalzo et al.

SCIENTIFIC REPORTS (2020)

Review Biochemistry & Molecular Biology

Prenatal Hypoxia and Placental Oxidative Stress: Insights from Animal Models to Clinical Evidences

Serena Silvestro et al.

ANTIOXIDANTS (2020)

Review Immunology

Placental Microbial Colonization and Its Association With Pre-eclampsia

Kehinde S. Olaniyi et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Review Cardiac & Cardiovascular Systems

Preeclampsia-Pathophysiology and Clinical Presentations JACC State-of-the-Art Review

Christopher W. Ives et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Article Biotechnology & Applied Microbiology

Altered Bioavailability of Nitric Oxide and L-Arginine Is a Key Determinant of Endothelial Dysfunction in Preeclampsia

Worlanyo Tashie et al.

BIOMED RESEARCH INTERNATIONAL (2020)

Review Immunology

Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease

Jeffery A. Goldstein et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Medicine, General & Internal

Lipidomic profiling of chorionic villi in the placentas of women with chronic venous disease

Miguel A. Ortega et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)

Article Medicine, General & Internal

Maternal and Perinatal Outcomes in Patients with Suspected COVID-19 and Their Relationship with a Negative RT-PCR Result

Yolanda Cunarro-Lopez et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Obstetrics & Gynecology

Gestational Hypertension and Preeclampsia

Jimmy Espinoza et al.

OBSTETRICS AND GYNECOLOGY (2020)

Article Obstetrics & Gynecology

Angiogenic factors for prediction of preeclampsia and intrauterine growth restriction onset in high-risk women: AngioPred study

Tiphaine Raia-Barjat et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2019)

Review Endocrinology & Metabolism

Knowledge Gaps and Emerging Research Areas in Intrauterine Growth Restriction-Associated Brain Injury

Bobbi Fleiss et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Endocrinology & Metabolism

Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact

Atul Malhotra et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Cell Biology

Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction

Samprikta Manna et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Immunology

The two-stage placental model of preeclampsia: An update

Anne Cathrine Staff

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2019)

Review Endocrinology & Metabolism

Causes and Consequences of the Dysregulated Maternal Renin-Angiotensin System in Preeclampsia

Eugenie R. Lumbers et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Developmental Biology

Development of the human placenta

Margherita Y. Turco et al.

DEVELOPMENT (2019)

Article Medical Laboratory Technology

Association of pro- and anti-inflammatory cytokines in preeclampsia

Ruby Aggarwal et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2019)

Review Biochemistry & Molecular Biology

Protein Misfolding during Pregnancy: New Approaches to Preeclampsia Diagnostics

Elizaveta M. Gerasimova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Medicine, General & Internal

Chronic venous insufficiency and varicose veins of the lower extremities

Young Jin Youn et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2019)

Review Medicine, Research & Experimental

The Seriousness of Chronic Venous Disease: A Review of Real-World Evidence

Alun H. Davies

ADVANCES IN THERAPY (2019)

Review Medicine, General & Internal

Association of Low Maternal Pregnancy-associated Plasma Protein A with Adverse Perinatal Outcome

Panagiotis Antsaklis et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2019)

Review Medicine, General & Internal

Calcium supplementation commencing before or early in pregnancy, for preventing hypertensive disorders of pregnancy

G. Justus Hofmeyr et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2019)

Review Immunology

Immune responses at the maternal-fetal interface

Stephanie E. Ander et al.

SCIENCE IMMUNOLOGY (2019)

Review Obstetrics & Gynecology

The role of aspirin, heparin, and other interventions in the prevention and treatment of fetal growth restriction

Katie M. Groom et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2018)

Review Obstetrics & Gynecology

Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis

Stephanie Roberge et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2018)

Review Obstetrics & Gynecology

Pathophysiology of placental-derived fetal growth restriction

Graham J. Burton et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2018)

Review Biochemistry & Molecular Biology

HELLP Syndrome Pathophysiology and Current Therapies

Kedra Wallace et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2018)

Review Biochemistry & Molecular Biology

Oxidative Stress in Preeclampsia and Placental Diseases

Rajaa Aouache et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Pediatrics

Consensus Based Definition of Growth Restriction in the Newborn

Irene M. Beune et al.

JOURNAL OF PEDIATRICS (2018)

Article Developmental Biology

Knowledge needed about the exchange physiology of the placenta

Colin P. Sibley et al.

PLACENTA (2018)

Article Pediatrics

Screening for fetal growth restriction and placental insufficiency

Melanie C. Audette et al.

SEMINARS IN FETAL & NEONATAL MEDICINE (2018)

Editorial Material Acoustics

Pre-eclampsia and the cardiovascular-placental axis

B. Thilaganathan

ULTRASOUND IN OBSTETRICS & GYNECOLOGY (2018)

Article Obstetrics & Gynecology

Predictive value of sFlt-1, PlGF, sFlt-1/PlGF ratio and PAPP-A for late-onset preeclampsia and IUGR between 32 and 37 weeks of pregnancy

C. Birdir et al.

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH (2018)

Review Immunology

Defense and infection of the human placenta

Amy Heerema-McKenney

APMIS (2018)

Article Biochemistry & Molecular Biology

Trophoblast: The central unit of fetal growth, protection and programming

Frantisek Staud et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

Article Cell Biology

Increase and Redistribution of Sex Hormone Receptors in Premenopausal Women Are Associated with Varicose Vein Remodelling

Natalio Garcia-Honduvilla et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

Article Multidisciplinary Sciences

Single-cell reconstruction of the early maternal-fetal interface in humans

Roser Vento-Tormo et al.

NATURE (2018)

Article Multidisciplinary Sciences

Maternal stress and placental function, a study using questionnaires and biomarkers at birth

Birthe R. Dahlerup et al.

PLOS ONE (2018)

Article Cardiac & Cardiovascular Systems

Cardiovascular adaptation to extrauterine life after intrauterine growth restriction

Luciana Rodriguez-Guerineau et al.

CARDIOLOGY IN THE YOUNG (2018)

Article Obstetrics & Gynecology

PlGF in a clinical setting of pregnancies at risk of preeclampsia and/or intrauterine growth restriction

Irene Cetin et al.

Journal of Maternal-Fetal & Neonatal Medicine (2017)

Review Developmental Biology

Review: Maternal health and the placental microbiome

Elise Pelzer et al.

PLACENTA (2017)

Review Radiology, Nuclear Medicine & Medical Imaging

Placental Imaging: Normal Appearance with Review of Pathologic Findings

Shaimaa Fadl et al.

RADIOGRAPHICS (2017)

Article Acoustics

ASPRE trial: performance of screening for preterm pre-eclampsia

D. L. Rolnik et al.

ULTRASOUND IN OBSTETRICS & GYNECOLOGY (2017)

Article Obstetrics & Gynecology

Associations between maternal serum free beta human chorionic gonadotropin (β-hCG) levels and adverse pregnancy outcomes

P. Sirikunalai et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2016)

Review Neurosciences

The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming

Stefanie L. Bronson et al.

NEUROPSYCHOPHARMACOLOGY (2016)

Article Obstetrics & Gynecology

The hemodynamics of late-onset intrauterine growth restriction by MRI

Meng Yuan Zhu et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2016)

Review Immunology

The Role of Decidual Macrophages During Normal and Pathological Pregnancy

Fen Ning et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2016)

Article Endocrinology & Metabolism

Angiogenic balance (sFlt-1/PlGF) and preeclampsia

Edouard Lecarpentier et al.

ANNALES D ENDOCRINOLOGIE (2016)

Review Cardiac & Cardiovascular Systems

Physiological changes in pregnancy

Priya Soma-Pillay et al.

CARDIOVASCULAR JOURNAL OF AFRICA (2016)

Review Cardiac & Cardiovascular Systems

Pre-eclampsia: its pathogenesis and pathophysiolgy

P. Gathiram et al.

CARDIOVASCULAR JOURNAL OF AFRICA (2016)

Review Peripheral Vascular Disease

Placental Ischemia and Resultant Phenotype in Animal Models of Preeclampsia

Babbette LaMarca et al.

CURRENT HYPERTENSION REPORTS (2016)

Article Obstetrics & Gynecology

Preeclampsia; short and long-term consequences for mother and neonate

Anouk Bokslag et al.

EARLY HUMAN DEVELOPMENT (2016)

Editorial Material Environmental Sciences

Lasting Impact of an Ephemeral Organ The Role of the Placenta in Fetal Programming

Lindsey Konkel

ENVIRONMENTAL HEALTH PERSPECTIVES (2016)

Review Physiology

The role of morphology in mathematical models of placental gas exchange

A. S. Serov et al.

JOURNAL OF APPLIED PHYSIOLOGY (2016)

Article Medicine, General & Internal

Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia

Harald Zeisler et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Physiology

PLACENTAL ORIGINS OF CHRONIC DISEASE

Graham J. Burton et al.

PHYSIOLOGICAL REVIEWS (2016)

Review Obstetrics & Gynecology

The endocrine function of human placenta: an overview

Mariana A. Costa

REPRODUCTIVE BIOMEDICINE ONLINE (2016)

Article Nutrition & Dietetics

Calcium Supplementation to Prevent Preeclampsia: Translating Guidelines into Practice in Low-Income Countries

Moshood O. Omotayo et al.

ADVANCES IN NUTRITION (2016)

Review Physiology

Placental Nutrient Transport and Intrauterine Growth Restriction

Francesca Gaccioli et al.

FRONTIERS IN PHYSIOLOGY (2016)

Review Obstetrics & Gynecology

Oxidative stress in pregnancy and reproduction

Kate Duhig et al.

OBSTETRIC MEDICINE (2016)

Editorial Material Obstetrics & Gynecology

The placenta is the center of the chronic disease universe

Kent L. Thornburg et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2015)

Editorial Material Obstetrics & Gynecology

What is the placenta?

Graham J. Burton et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2015)

Review Obstetrics & Gynecology

Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance

Chong Jai Kim et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2015)

Review Biochemistry & Molecular Biology

Combined Screening for Early Detection of Pre-Eclampsia

Hee Jin Park et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Review Biology

The placenta: a multifaceted, transient organ

Graham J. Burton et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)

Review Biotechnology & Applied Microbiology

Oxidative Stress in Placenta: Health and Diseases

Fan Wu et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Obstetrics & Gynecology

Maternal sleep duration and complaints of vital exhaustion during pregnancy is associated with placental abruption

Chunfang Qiu et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2015)

Article Physiology

Placental Gas Exchange and the Oxygen Supply to the Fetus

Anthony M. Carter

COMPREHENSIVE PHYSIOLOGY (2015)

Review Peripheral Vascular Disease

Risk factors and effective management of preeclampsia

Fred A. English et al.

INTEGRATED BLOOD PRESSURE CONTROL (2015)

Review Endocrinology & Metabolism

Exercise as an intervention to improve metabolic outcomes after intrauterine growth restriction

Kathryn L. Gatford et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)

Article Cardiac & Cardiovascular Systems

Varicose Veins

Gregory Piazza

CIRCULATION (2014)

Editorial Material Cardiac & Cardiovascular Systems

Cardiovascular Physiology

Monika Sanghavi et al.

CIRCULATION (2014)

Article Developmental Biology

T cell behavior at the maternal-fetal interface

Patrice Nancy et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2014)

Article Immunology

Intrauterine Growth Restriction Caused by Underlying Congenital Cytomegalovirus Infection

Lenore Pereira et al.

JOURNAL OF INFECTIOUS DISEASES (2014)

Article Immunology

Preeclampsia and uteroplacental acute atherosis: immune and inflammatory factors

Anne Cathrine Staff et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2014)

Review Urology & Nephrology

Pre-eclampsia part 1: current understanding of its pathophysiology

Tinnakorn Chaiworapongsa et al.

NATURE REVIEWS NEPHROLOGY (2014)

Article Obstetrics & Gynecology

Clinical Risk Factors for Preeclampsia in the 21st Century

Emmanuelle Pare et al.

OBSTETRICS AND GYNECOLOGY (2014)

Article Obstetrics & Gynecology

Maternal Morbidity Associated With Early-Onset and Late-Onset Preeclampsia

Sarka Lisonkova et al.

OBSTETRICS AND GYNECOLOGY (2014)

Review Developmental Biology

Review: Where is the maternofetal interface?

L. W. Chamley et al.

PLACENTA (2014)

Article Developmental Biology

Cholestatic pregnancy is associated with reduced placental 11βHSD2 expression

M. Martineau et al.

PLACENTA (2014)

Article Developmental Biology

The Human Placenta Project: Placental structure, development, and function in real time

A. E. Guttmacher et al.

PLACENTA (2014)

Article Multidisciplinary Sciences

Aberrantly Expressed lncRNAs in Primary Varicose Great Saphenous Veins

Xiang Li et al.

PLOS ONE (2014)

Review Physiology

Endothelial dysfunction stress and preeclampsia: role of oxidative Stress

Lissette C. Sanchez-Aranguren et al.

FRONTIERS IN PHYSIOLOGY (2014)

Review Immunology

Innate immune system and preeclampsia

Alejandra Perez-Sepulveda et al.

FRONTIERS IN IMMUNOLOGY (2014)

Article Obstetrics & Gynecology

Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease

Sarka Lisonkova et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2013)

Review Immunology

Angiotensin II Type 1 Receptor Autoantibody (AT1-AA)-Mediated Pregnancy Hypertension

Florian Herse et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2013)

Review Immunology

CD8+ Effector T Cells at the Fetal-Maternal Interface, Balancing Fetal Tolerance and Antiviral Immunity

Tamara Tilburgs et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2013)

Article Immunology

Maternal Floor Infarction/Massive Perivillous Fibrin Deposition: A Manifestation of Maternal Antifetal Rejection?

Roberto Romero et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2013)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Article Medicine, General & Internal

The effect of maternal exercise during pregnancy on abnormal fetal growth

Vlatka Tomic et al.

CROATIAN MEDICAL JOURNAL (2013)

Review Endocrinology & Metabolism

Placental regulation of fetal nutrient supply

Elvira Larque et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2013)

Editorial Material Peripheral Vascular Disease

Spiral Artery Remodeling in Preeclampsia Revisited

Suzanne D. Burke et al.

HYPERTENSION (2013)

Review Cell Biology

A leading role for the immune system in the pathophysiology of preeclampsia

Estibalitz Laresgoiti-Servitje

JOURNAL OF LEUKOCYTE BIOLOGY (2013)

Article Surgery

Venous disease in women: Epidemiology, manifestations, and treatment

Joann M. Lohr et al.

JOURNAL OF VASCULAR SURGERY (2013)

Review Biochemistry & Molecular Biology

Placental trophoblast cell differentiation: Physiological regulation and pathological relevance to preeclampsia

Lei Ji et al.

MOLECULAR ASPECTS OF MEDICINE (2013)

Article Obstetrics & Gynecology

Maternal Serum Hormonal Factors in the Pathogenesis of Preeclampsia

Eugenia Maria Assuncao Salustiano et al.

OBSTETRICAL & GYNECOLOGICAL SURVEY (2013)

Article Developmental Biology

Maternal cotyledons at birth predict blood pressure in childhood

D. Barker et al.

PLACENTA (2013)

Article Multidisciplinary Sciences

Effect of Exercise Training on Enos Expression, NO Production and Oxygen Metabolism in Human Placenta

Robinson Ramirez-Velez et al.

PLOS ONE (2013)

Article Obstetrics & Gynecology

Introduction to ISSHP new classification of preeclampsia

Andrea L. Tranquilli

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health (2013)

Article Obstetrics & Gynecology

Intrauterine Growth Restriction (IUGR): Etiology and Diagnosis

Anju Suhag et al.

CURRENT OBSTETRICS AND GYNECOLOGY REPORTS (2013)

Review Obstetrics & Gynecology

Physical exercise during pregnancy: a systematic review

Simony L. Nascimento et al.

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY (2012)

Article Endocrinology & Metabolism

The thrifty phenotype hypothesis revisited

A. A. Vaag et al.

DIABETOLOGIA (2012)

Article Cardiac & Cardiovascular Systems

Coronary Flow in Neonates with Impaired Intrauterine Growth

Elhadi H. Aburawi et al.

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY (2012)

Review Cell Biology

Vessel remodelling, pregnancy hormones and extravillous trophoblast function

Jessie Z. -J. Chen et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)

Article Developmental Biology

The emerging role of mTORC1 signaling in placental nutrient-sensing

T. Jansson et al.

PLACENTA (2012)

Review Developmental Biology

Review: Placenta, evolution and lifelong health

R. M. Lewis et al.

PLACENTA (2012)

Article Pediatrics

Long term respiratory consequences of intrauterine growth restriction

Katharine Pike et al.

SEMINARS IN FETAL & NEONATAL MEDICINE (2012)

Review Obstetrics & Gynecology

Prevention of Preeclampsia

Sammya Bezerra Maia e Holanda Moura et al.

JOURNAL OF PREGNANCY (2012)

Article Multidisciplinary Sciences

Inflammation and pregnancy: the role of the immune system at the implantation site

Gil Mor et al.

REPRODUCTIVE SCIENCE (2011)

Article Obstetrics & Gynecology

Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy

Jennifer A. Hutcheon et al.

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY (2011)

Review Obstetrics & Gynecology

A Critical Review of Early-Onset and Late-Onset Preeclampsia

Dahlia Raymond et al.

OBSTETRICAL & GYNECOLOGICAL SURVEY (2011)

Article Developmental Biology

Deportation of syncytial sprouts from the term human placenta

G. J. Burton

PLACENTA (2011)

Article Hematology

Placental pathology in pregnancy complications

Berthold Huppertz

THROMBOSIS RESEARCH (2011)

Review Obstetrics & Gynecology

Consequences in Infants That Were Intrauterine Growth Restricted

Erich Cosmi et al.

JOURNAL OF PREGNANCY (2011)

Review Obstetrics & Gynecology

Diagnosis and Management of Fetal Growth Restriction

Jacqueline E. A. K. Bamfo et al.

JOURNAL OF PREGNANCY (2011)

Letter Pediatrics

Intrauterine growth retardation - small events, big consequences

Taimur Saleem et al.

ITALIAN JOURNAL OF PEDIATRICS (2011)

Review Obstetrics & Gynecology

Placental Insufficiency and Fetal Growth Restriction

Krishna Usha et al.

JOURNAL OF OBSTETRICS AND GYNECOLOGY OF INDIA (2011)

Review Immunology

The Immune System in Pregnancy: A Unique Complexity

Gil Mor et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2010)

Article Obstetrics & Gynecology

Role of oxidative stress in the pathogenesis of preeclampsia

Imran A. Siddiqui et al.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2010)

Review Reproductive Biology

Maternal Undernutrition Influences Placental-Fetal Development

Louiza Belkacemi et al.

BIOLOGY OF REPRODUCTION (2010)

Article Obstetrics & Gynecology

Endometrial Decidualization: Of Mice and Men

Cyril Y. Ramathal et al.

SEMINARS IN REPRODUCTIVE MEDICINE (2010)

Article Physiology

Sex-specific alterations in placental 11β-hydroxysteroid dehydrogenase 2 activity and early postnatal clinical course following antenatal betamethasone

Michael J. Stark et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2009)

Article Developmental Biology

The Two Stage Model of Preeclampsia: Variations on the Theme

J. M. Roberts et al.

PLACENTA (2009)

Review Peripheral Vascular Disease

Endoglin in angiogenesis and vascular diseases

Peter ten Dijke et al.

ANGIOGENESIS (2008)

Review Peripheral Vascular Disease

Placental origins of preeclampsia - Challenging the current hypothesis

Berthold Huppertz

HYPERTENSION (2008)

Review Immunology

Trophoblast immune receptors in maternal-fetal tolerance

Joan K. Riley

IMMUNOLOGICAL INVESTIGATIONS (2008)

Review Pathology

The anatomy of the normal placenta

B. Huppertz

JOURNAL OF CLINICAL PATHOLOGY (2008)

Review Biochemistry & Molecular Biology

The fate and effects of xenobiotics in human placenta

Paivi Myllynen et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2007)

Review Obstetrics & Gynecology

Ethanol and the placenta: A review

Larry Burd et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2007)

Article Medicine, Research & Experimental

Intensive glycemic control in diabetic pregnancy with intrauterine growth restriction in detrimental to fetus

Rakesh M. Parikh et al.

MEDICAL HYPOTHESES (2007)

Review Biochemistry & Molecular Biology

The role of the immune system in preeclampsia1

Shigeru Saito et al.

MOLECULAR ASPECTS OF MEDICINE (2007)

Review Reproductive Biology

P-glycoprotein in the placenta: Expression, localization, regulation and function

Martina Ceckova-Novotna et al.

REPRODUCTIVE TOXICOLOGY (2006)

Article Peripheral Vascular Disease

The role of RAS in the pathogenesis of preeclampsia

Dinesh M. Shah

CURRENT HYPERTENSION REPORTS (2006)

Article Neurosciences

Placental adaptive responses and fetal programming

L Myatt

JOURNAL OF PHYSIOLOGY-LONDON (2006)

Article Biochemistry & Molecular Biology

Soluble endoglin contributes to the pathogenesis of preeclampsia

Shivalingappa Venkatesha et al.

NATURE MEDICINE (2006)

Article Endocrinology & Metabolism

Molecular evidence of placental hypoxia in preeclampsia

N Soleymanlou et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)

Review Multidisciplinary Sciences

Latest advances in understanding preeclampsia

CW Redman et al.

SCIENCE (2005)

Article Obstetrics & Gynecology

The relationship between plasma levels of leptin and androgen in healthy and preeclamptic pregnant women

Y Atamer et al.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2004)

Article Developmental Biology

Trophoblast oxidative stress, antioxidants and pregnancy outcome - A review

L Poston et al.

PLACENTA (2004)

Article Hematology

Growth and function of the normal human placenta

NM Gude et al.

THROMBOSIS RESEARCH (2004)

Article Developmental Biology

The role of the placenta in fetal programming - A review

KM Godfrey

PLACENTA (2002)

Article Physiology

Expression of members of the multidrug resistance protein family in human term placenta

MV St-Pierre et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2000)

Article Obstetrics & Gynecology

Villous sprouting: fundamental mechanisms of human placental development

M Castellucci et al.

HUMAN REPRODUCTION UPDATE (2000)