4.6 Article

Generation and Characterization of an Inducible Cx43 Overexpression System in Mouse Embryonic Stem Cells

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Importance of Cx43 for Right Ventricular Function

Kerstin Boengler et al.

Summary: This article focuses on the importance of connexin 43 (Cx43) for the developing heart, discussing its expression and localization in diseased right ventricle (RV) conditions such as tetralogy of Fallot and pulmonary hypertension. Other connexin molecules involved in RV pathophysiology are also introduced, along with therapeutic strategies aiming to improve RV function in pulmonary hypertension.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cardiac & Cardiovascular Systems

What we know about cardiomyocyte dedifferentiation

Yike Zhu et al.

Summary: The article discusses the importance of cardiomyocyte dedifferentiation in cardiac regeneration and the challenges in studying it. Despite some genes being proven to promote endogenous CM proliferation and the belief that CM dedifferentiation precedes cell division, there are still knowledge gaps and controversies surrounding the definition of CM dedifferentiation.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2021)

Article Biochemistry & Molecular Biology

Astrocytes and Epilepsy

Devin K. Binder et al.

Summary: Changes in astrocyte channels, transporters, and metabolism are closely linked to seizure generation and epilepsy, with alterations in potassium, glutamate, water and adenosine homeostasis contributing to hyperexcitability and epileptogenesis. Understanding the role of astrocytes in epilepsy offers potential for identifying novel astrocyte-specific therapeutic targets.

NEUROCHEMICAL RESEARCH (2021)

Review Biochemistry & Molecular Biology

Connexins in the Heart: Regulation, Function and Involvement in Cardiac Disease

Antonio Rodriguez-Sinovas et al.

Summary: Connexins are transmembrane proteins that are crucial for cardiac physiology, facilitating electrical coupling between cardiomyocytes. Beyond cell-to-cell communication, connexins also play roles in cell death and survival, with additional functions such as opening of hemichannels and involvement in cardioprotection and cell growth. In-depth exploration of connexin biology sheds light on their implications in various aspects of cardiac pathophysiology.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy

Kenichi Kimura et al.

Summary: An amino acid exchange (P209L) in human co-chaperone BAG3 leads to severe childhood restrictive cardiomyopathy. The authors have generated humanized transgenic mouse models that mimic the disease and provide insights into pathogenic mechanisms.

NATURE COMMUNICATIONS (2021)

Review Cell Biology

Remodeling of Cardiac Gap Junctional Cell-Cell Coupling

Stefan Dhein et al.

Summary: The heart relies on gap junction channels to maintain cell-cell coupling for efficient and rapid electrical conduction. Connexin expression and gap junction localization play crucial roles in modulating cardiac electrical properties, ultimately affecting cardiac stability and function.

CELLS (2021)

Review Cardiac & Cardiovascular Systems

Peptidic Connexin43 Therapeutics in Cardiac Reparative Medicine

Spencer R. Marsh et al.

Summary: Channels formed by Connexin (Cx43) are associated with various heart diseases, with some Cx43 mimetic peptides showing therapeutic potential and advancing to clinical testing. However, challenges in drug delivery, stability, and tissue penetration have caused reluctance in the pharmaceutical industry to translate peptidic therapeutics to the clinic. Novel drug delivery technologies like nanoparticles may provide solutions to these issues.

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE (2021)

Review Genetics & Heredity

Engineering adeno-associated virus vectors for gene therapy

Chengwen Li et al.

NATURE REVIEWS GENETICS (2020)

Review Cardiac & Cardiovascular Systems

Heritable arrhythmia syndromes associated with abnormal cardiac sodium channel function: ionic and non-ionic mechanisms

Mathilde R. Rivaud et al.

CARDIOVASCULAR RESEARCH (2020)

Article Biochemistry & Molecular Biology

Src Regulation of Cx43 Phosphorylation and Gap Junction Turnover

Joell L. Solan et al.

BIOMOLECULES (2020)

Article Multidisciplinary Sciences

Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision

Philipp Makowka et al.

NATURE COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Human diseases associated with connexin mutations

Miduturu Srinivas et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)

Article Biochemistry & Molecular Biology

The connexin 43 C-terminus: A tail of many tales

Edward Leithe et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)

Article Multidisciplinary Sciences

Visualization of Cell Cycle Variations and Determination of Nucleation in Postnatal Cardiomyocytes

Alexandra Raulf et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2017)

Article Cardiac & Cardiovascular Systems

Connexin45 Provides Optimal Atrioventricular Nodal Conduction in the Adult Mouse Heart

Marina Frank et al.

CIRCULATION RESEARCH (2012)

Article Multidisciplinary Sciences

Electrophysiology of Single and Aggregate Cx43 Hemichannels

Cole Brokamp et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycle

Michael Hesse et al.

NATURE COMMUNICATIONS (2012)

Article Biochemistry & Molecular Biology

Residual Cx45 and its relationship to Cx43 in Murine ventricular myocardium

Mingwei Bao et al.

CHANNELS (2011)

Article Cell Biology

Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1

J. Matthew Rhett et al.

MOLECULAR BIOLOGY OF THE CELL (2011)

Review Oncology

Cell membrane permeabilization via connexin hemichannels in living and dying cells

Juan C. Saez et al.

EXPERIMENTAL CELL RESEARCH (2010)

Article Cardiac & Cardiovascular Systems

Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria

Kerstin Boengler et al.

BASIC RESEARCH IN CARDIOLOGY (2009)

Review Cardiac & Cardiovascular Systems

Remodelling of gap junctions and connexin expression in diseased myocardium

Nicholas J. Severs et al.

CARDIOVASCULAR RESEARCH (2008)

Article Biochemistry & Molecular Biology

The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans

Radoslaw Dobrowolski et al.

HUMAN MOLECULAR GENETICS (2008)

Article Multidisciplinary Sciences

Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia

Wilhelm Roell et al.

NATURE (2007)

Article Cell Biology

Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters

Junjie Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)

Article Multidisciplinary Sciences

Developmental and adult phenotyping directly from mutant embryonic stem cells

Sophia H. L. George et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Medicine, General & Internal

Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation

Michael H. Gollob et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Review Biochemistry & Molecular Biology

Life cycle of connexins in health and disease

DW Laird

BIOCHEMICAL JOURNAL (2006)

Article Cardiac & Cardiovascular Systems

Modulation of cardiac gap junction expression and arrhythmic susceptibility

SB Danik et al.

CIRCULATION RESEARCH (2004)

Review Cardiac & Cardiovascular Systems

Gap junctions and the connexin protein family

G Söhl et al.

CARDIOVASCULAR RESEARCH (2004)

Article Multidisciplinary Sciences

Gating and regulation of connexin 43 (U43) hemichannels

JE Contreras et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Cardiac & Cardiovascular Systems

Differentiation of pluripotent embryonic stem cells into cardiomyocytes

KR Boheler et al.

CIRCULATION RESEARCH (2002)

Article Cardiac & Cardiovascular Systems

Paradoxical overexpression and translocation of connexin43 in homocysteine-treated endothelial cells

H Li et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2002)

Article Multidisciplinary Sciences

Clustering of connexin 43-enhanced green fluorescent protein gap junction channels and functional coupling in living cells

FF Bukauskas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)