Golgi Apparatus Regulates Plasma Membrane Composition and Function

Golgi apparatus is the central component of the mammalian secretory pathway and it regulates the biosynthesis of the plasma membrane through three distinct but interacting processes: (a) processing of protein and lipid cargoes; (b) creation of a sharp transition in membrane lipid composition by non-vesicular transport of lipids; and (c) vesicular sorting of proteins and lipids at the trans-Golgi network to target them to appropriate compartments. We discuss the molecules involved in these processes and their importance in physiology and development. We also discuss how mutations in these molecules affect plasma membrane composition and signaling leading to genetic diseases and cancer.

Automated summary

This article discusses the central role of the Golgi apparatus in the mammalian secretory pathway and its regulation of plasma membrane biosynthesis through three distinct processes. It also explores the importance of the molecules involved in these processes in physiology and development, as well as how mutations in these molecules can lead to genetic diseases and cancer.